Non-Weight Loss Benefits of GLP-1 Medications

The Hidden Benefits of GLP-1 Medications (Beyond Weight Loss)

In this episode of Healthier Ever After, Rick and Greg take a deep dive into one of the most exciting and rapidly evolving topics in medicine today: the non-weight loss benefits of GLP-1 medications.

While drugs like semaglutide and tirzepatide are widely known for their powerful effects on weight loss, this conversation explores a much bigger story—one that’s unfolding through emerging research and real-world clinical experience.

What You’ll Learn in This Episode:

1. Cardiovascular Protection (Even Before Weight Loss)

•New research shows up to a 41% reduction in major cardiovascular events within the first 6 months of starting GLP-1 therapy.

•Benefits begin as early as 20 days, suggesting these medications have direct heart-protective effects, not just indirect benefits from weight loss.

2. Kidney Health & Disease Prevention

•GLP-1 medications have been shown to reduce the progression of kidney disease by ~24%.

•Particularly impactful for patients with type 2 diabetes, where kidney complications are common.

3. Anti-Inflammatory Effects & Joint Relief

•Beyond reducing joint stress through weight loss, GLP-1s appear to have direct anti-inflammatory properties.

•Patients frequently report less joint pain and improved mobility, even at lower doses.

4. Mental Health, Mood & Addiction

•These medications interact with the brain’s dopamine reward system, which may:

•Improve mood

•Reduce cravings

•Decrease alcohol use and addictive behaviors

•Early data suggests potential applications in addiction treatment and psychiatric conditions.

5. Future Potential: Brain Health & Neurodegenerative Disease

•Ongoing research is exploring whether GLP-1s may:

•Protect against Alzheimer’s and Parkinson’s disease

•Improve cognitive function

•Reduce neuroinflammation

Key Takeaway

GLP-1 medications are quickly evolving from “weight loss drugs” into something much bigger—a potential cornerstone therapy for metabolic, cardiovascular, and even neurological health.

As Rick and Greg discuss, the medical community is already shifting—from skepticism to widespread adoption—as study after study confirms these broader benefits.

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Bonus Segment: Supplement of the Week

The episode wraps with a discussion of their Hair, Skin & Nails Essential supplement, designed to support:

•Hair growth

•Nail strength

•Skin health

This is especially helpful for patients experiencing changes related to weight loss or aging, with anecdotal reports of improved hair thickness and faster nail growth.

⸻

If you’re interested in the science behind GLP-1 medications—or wondering if they may offer benefits beyond weight loss—this episode is packed with insights you won’t want to miss.

Transcript

SPEAKER_01 0:00

And here we go. We are live again. Welcome back, Greg. Hey, welcome. Uh, we're here on Healthier Raptor. Uh, we're gonna talk about some uh interesting, uh interesting non-weight loss benefits of uh GLP1 medications, I think, tonight, right?

SPEAKER_00 0:14

Yeah, yeah. We both really like this topic. We talk about the the non-weight weight loss benefits of GLP1s all the time uh amongst ourselves, and we're like, gosh, what a cool topic to be able to dive into. Um, because I think that the the hype around these has been just the weight loss, but we I mean there's so many other benefits.

SPEAKER_01 0:31

And there's study and study. We can pull up some studies maybe even. I'll I'll get my laptop out. But we get get peppered with like, hey, there's a new study. Hey, somebody just found out this. Um, and so so we'll get into that a little bit. Uh, before we get started, remember this is uh for educational and informational purposes only. We strongly encourage you to seek the care and consultation with your medical provider before starting any weight loss program, exercise program, uh supplements, or other medication. Um with that, we'll get into it. Uh a couple of weeks last couple weeks we had Clip on Clippable. That was awesome. So we're talking about uh pharmacies, Jim P1's history. Um they do not come directly from Hila Monsters.

SPEAKER_00 1:09

Uh you know, every time I talk to Cliff, I've talked to Cliff several times on podcasts and things like that. Every time I talk to that guy, I feel like I learn it's just like going back to school. He just has so much information from a medic medication standpoint, uh, from that pharmacy standpoint. So it's really awesome having him on. Uh I'm sure we'll have him on in the future to discuss other things.

SPEAKER_01 1:29

Well, I looked, I loved how he talked about like like really, you know, we talk about compounding pharmacies like they're some new thing or they're the trendy thing, but but really they are the the relics of the origin story of pharmacies, right? There's the apothecaries, the guy you mix all this stuff up, and and and it really is a a personalized, individualized, uh meticulous, deliberate process uh to help you know people uh get the get the effects and response that that we want from some particular dosing, right?

SPEAKER_00 2:02

I mean, uh, and even sometimes things that just really aren't made in big, you know, for big box pharmacy distribution. Uh some people just have individual needs, individual diseases that require um customization, and that's where compound pharmacies come in. And it's uh I I think you're I think it's yeah, I think it's awesome to think about like pharmacies, compound pharmacies were the OG. They were the ones that were the actually like that's what a pharmacy was, is you worked with a doctor and a pharmacist to be able to come up with these formulations, and now they're looked at as like kind of more um uh these specialty pharmacies that are not really familiar to most people. And um, and and that's really just not the case. The truth is that they are the ones who actually were the OGs of pharmacy and these big box pharmacies, which we all are have become accustomed to and have their place uh in medicine for sure. They're the ones who are um actually just uh more new. They're the ones that are not um haven't been around for as long.

SPEAKER_01 3:00

Right, right. So, so talking about that and and different things, one of the things we just we wanted to talk about tonight is is you know, we've been talking a lot lately about the GLP1 medicines, the the semaglutide, trzepatite, your Wagovi, your Ozempic, your Zep bound, and and and how people use those for weight loss and how that kind of came about. They were originally diabetic medications, and it was discovered, you know, that hey, the biggest side effect of this is weight loss. Yeah, and that now they're like all the rage, right? Well, well, it's it's just it's like on the weekly, it seems like there's some new study, there's some new thing, there's somebody discovered another thing. I mean, there's there are studies after studies all over the world. We'll talk about one from Spain, from Malaga Spain today, but um that that are showing more benefits, you know. It's not not like, hey, we have this diabetes medicine, and we just discovered that like everybody that takes it loses a bunch of weight. That that same process is happening, but with with cardiovascular system, kidney health, liver health, gut health, like mental health. Yeah, and so so we wanted to kind of dive in some of those today and see about some of the just these non-weight loss uh benefits that continue to be researched and and are constantly being kind of discovered more and honed in on a little bit.

SPEAKER_00 4:17

You know, I I talked to a pharmacist that I work with in the emergency department with me and Rick were work with, and you know, he uh when the GLP ones first started coming out, you know, he knew that I had uh dealt with these medications for a little while. And that was when they were kind of still a little bit on the weight loss front, still a little bit more like, hey, what's going on with these? Uh and he said, you know, he's like, I would have patient after patient come in that would have some kind of disease process that brought him to the emergency department. And he said, Oh, I he saw he, you know, they reconcile medications in the ER. And he's like, I would reconcile their medication. Listen, I'd immediately see that, oh, they're on a GLP one. So then he'd say, Well, I I wanted to kind of prove that you know some of these problems coming into the ER will like that's why they were coming in. That's why they're coming in. He's like, So I'd start diving in. Oh, this patient's here with kidney failure. Oh, I see that they're on a GLP one. So he's he'd go diving into the research and seeing what he could find. And you know, he he never told me he was doing this. He told me after the fact, he said, You do a lot with those GLP ones. And I said, Yeah. He said, You know, I've been kind of telling me what he's been doing with all these patients. Oh, yeah, they're on a GLP one. Let me see if this is what caused their disease. Right. And he said, To my surprise, every single time I look at what they're here for and and that they're on a GLP one, it's actually the opposite. Everything I'm finding in the research, and all he's looking at is the, you know, he has no bias, he's just like looking at like kind of for the negative evidence. He's actually trying to find out, he's actually trying to find. And he's like, every time they they come in, and I'm like, yeah, this is the probably their issue. He said the research was would actually support uh the opposite that, oh, this helps with cardiovascular function, this helps with kidneys and liver and all these things that people would come in for. And he's like, I'm getting to the point where I'm wondering what these things don't fix, what they don't help, right? And it's funny just to hear his perspective uh not coming from that background and him like really trying to dive in and kind of find the negative in these, and him continually just keeping on coming up with the research. He's just using the very scientific approach, looking at the research that's available, and he just can't find he's like, they just they they help with this and they help with this and they help with this, and all these things that typically we're trying to keep people out of the ER for. He's like, a lot of these things they just they help with. So it was just that really opened my eyes when we had that conversation um about like kind of the perspective of the people that don't live in this world and even medical people that really don't dive into the GLP ones and how their education, because this is also relatively new. This their education when they went through school, when he went through pharmacy school, these weren't really a big topic of discussion.

SPEAKER_01 6:49

Yeah.

SPEAKER_00 6:50

Awesome. Okay.

SPEAKER_01 6:51

I'm gonna I'm gonna change this format. Yeah. Grab a laptop for a second.

SPEAKER_00 6:54

Grab the laptop. We got a lot of awesome.

SPEAKER_01 6:56

Pulled up a couple of things.

SPEAKER_00 6:57

Rick has a couple hundred on his laptop of like studies and just games.

SPEAKER_01 7:01

So I just pulled up a couple of these. So so we want, let's talk with cardiovascular L, right? Yeah, like anything you want to say just introduce that.

SPEAKER_00 7:08

Well, the biggest thing is that we know weight loss, we know weight loss helps with the cardiovascular system. There's no, I mean, that's not a secret. That's been ongoing and and known uh amongst medical professionals and and regular um people not in the medical field for forever. Uh, what we were surprised to learn is how much it helped when you were losing weight on a GLP one or even not losing weight, you were just on a GLP one. That's actually uh what's interesting about these studies is far beyond even the weight loss, they found that the GLP1s are significantly uh helpful in reducing cardiovascular risk. So let's talk about what that is. That's stroke, that's heart attack. Um, we were even reading uh study together that we were surprised that it it actually helped shape the heart, like the LV. So the left ventricle. This is uh this is obviously the the main worker of the heart, the one thing uh the kind of the last stop before uh the blood goes out to your body, that it re can reshape and actually reduce the size of the left ventricle. Right for anyone that doesn't know, that's a good thing. Right. Um, and we just we just were fascinated by all the different benefits.

SPEAKER_01 8:14

So okay, so I'm pulling up this one now. That the this is a study out of Malaga, Spain. Yeah, okay, and this is this is just last year. So so um this was done. This is the the title of this is called uh semaglutide may cut cardiovascular risk before weight loss. So they did this big study, and essentially uh the the takeaway home is that people who started semaglutide um within the first six months of taking it, there was a 41% reduction in major adverse cardiovascular events, is what they called it. Um and and there was significant benefits seen by day 20. Um and at six months uh there was a that 41% decrease. Now the the thing that's interesting about that is is that first six months where there's this huge reduction in cardiovascular events, like 53% reduction in cardiovascular death. Um 43% reduction in non-fatal heart attacks. My goodness. And and and and that's just that's that's before patients were seeing significant weight loss, right? Like the first six months, it's kind of the second six months or the next year, like where you really see some of that weight really coming off because as you're ramping up, there's just small dosing. And so so that's that's I think the takeaway on this particular study out of Spain is that um there's a significant reduction in cardiovascular risk even before you lose weight on the medicine.

SPEAKER_00 9:42

Like fascinating to me. Fascinating. I mean, and and it really just kind of shows you kind of what's I mean, what's coming. I mean, the G Z GLP1s, I mean, peptides have been around for a little while, but GLP1s, as far as that peptide goes, I mean, these are they are just barely cracking the door down on these things, like where they're just really, I mean, having that much benefit in reduction of cardiovascular disease before you've actually even lost any significant amount of weight is huge. Right.

SPEAKER_01 10:07

I mean, it's just such a that's kind of goes to show, once again, we know that and it kind of demonstrates that a lot of times the way in in my pea brain, sometimes I think about this is is well, sure, you lose a bunch of weight, and a lot of these secondary things are going to get better, but this is actually information that data that shows these are direct benefits of the medication of the medication that aren't just a secondary uh kind of side effect of losing some weight. I mean, that's they're good with that as well. But this is just a separate total benefit.

SPEAKER_00 10:36

Yeah, it's it's really fascinating. And you see it, I mean, you see it in clinic, right? You start talking to these people and they're feeling better and their outcomes uh seem to be better. It's hard, it's hard though, to take that anecdotal stuff in clinic and and you know, kind of put it all together because it's really just more um observational. These studies are the opposite of that, right? They just take the science and they put it all together, and this is how we get medical information. It's so fascinating that they're able to take this information and and and kind of put all together what we're observationally seeing in clinic and then putting it in a study. And and it's it's doing exactly what we kind of thought it was doing, but before it was like we didn't really have the evidence to support it. Now, with all the studies going on with this, we have like we're getting an overwhelming amount of evidence that this is a significant reduction in this. I mean, it's to the point now where I just I suspect um our next competition for GLP1s as far as prescribing them um are gonna be cardiologists, right?

SPEAKER_01 11:34

I mean, it's gonna I I I I am not gonna be surprised if this becomes a a staple of cardiovascular health in a cardiology clinic. It just there's there's just so much benefits.

SPEAKER_00 11:48

Too much overwhelming evidence. It's interesting the shift that I've even seen in the five years I've been doing uh my weight loss clinic and and then adding in GLP1s. At first, it was everyone, primary care providers, uh cardiologists saying, oh boy, you know, people would come in and get on them, and they'd be like, oh boy, be careful, be cautious. Uh, you really ought to look into that. That's not gonna be a good thing. You're gonna, you know, lose a little bit of weight, but it's not worth it. And interestingly enough, now I get referrals all the time from primary cares and cardiologists. And and and anyone that tells me they go see their cardiologist and says, Hey, I told my cardiologist I'm on a GLP one. And before it was met with, like, oh boy, you better be cautious. And now it's met with like, that is fantastic. Good for you. And it's so interesting because as this data comes out, as the research that we're talking about, and we'll talk about a bunch more. Um, it's interesting to watch the medical community get this information and they're like, Oh, this isn't this isn't a one-off study by the manufacturers of the medication. This is study after study after study, non-biased, you know, these double blind. I mean, they do all the things and um and they're just finding really good information.

SPEAKER_01 12:54

Yeah. So, so hearts are healthier.

unknown 12:57

Yeah.

SPEAKER_01 12:58

I mean, I mean, who doesn't want that? Well, all right, let's talk about let's talk about kidneys. Yeah. Um, this is another study. This is one. So this is excuse me. Uh this is um uh talking about Ozempic. This was uh released about a year ago in the FDA. This is just a kind of a news story about the FDA has approved semaglutide um for reducing the risk of worsening kidney disease and cardiovascular death in adults with type 2 diabetes and chronic kidney disease. So this was an international study, it's called the flow trial, uh involved several thousand individuals, and and essentially what it achieved, the end point was um a significant uh 24% relative risk reduction of kidney disease worsening. So if you have kidney disease, 24% reduced the chance of it getting worse, yeah, right? Um, end stage kidney disease developing and death due to cardiovascular disease. These were out, these were the the endpoints. Um compared to the placebo, that was 4.9% at three years. So so 24%, it's like a 20% hard reduction.

SPEAKER_00 14:03

For for anyone that doesn't know that 20% kind of sounds like a very small number, you're like, 20%, what's that? I mean, when you work in the medical field, 20% of anything increase or improvement in any area is massive. It's a it's a big deal. I think what what's interesting uh to point out about this is that to back up a little bit, um, diabetes is so tough. It's tough on a lot of the parts of the body, you know, the the heart, and and and we could go on and on and on. But um the kidneys in particular, we see a lot of diabetic patients that end up becoming uh having renal disease or or significant end stage renal disease, and and that's the kidneys. And so to watch this reduction uh in these patients, to watch that this can be kidney protective or renal protective is so cool. And it's it's uh we kind of knew a little bit about this, right? We know you get your diabetes under control that that uh you know that it's gonna help the kidneys. But when you start seeing that this is uh it's better than just getting your your diabetes under control. The medication actually has a direct effect on the kidneys. Yeah. Um, as a noted side effect of these medications, oftentimes it was it was noted in the first studies that um renal failure or kidney, acute kidney um injury was noted as a potential side effect. So you're like, wait a minute, I don't get that. They said it could affect my kidneys in a negative way. How is it helping them? Um, most of this is what I can draw out, anyways, from what I've read, is that it was um, you know, the studies have to take every side effect that happens during the studies.

SPEAKER_01 15:31

Right, and mention it.

SPEAKER_00 15:32

Yeah, they they have to say it. So um this wasn't significant, but what it was is that um a lot of these people were dehydrated, right? GLP1s slow down gastric emptying. A lot of people just weren't drinking enough water on these medications. We know that dehydration under any circumstances eventually is, and probably the number one reason we see acute kidney injury in the ER is dehydration, right? Yep. So that was more related to that, but of course, when done under the studies and people are not drinking as much water, then they get dehydrated, they get acute kidney injury. So when when and if you ever go on these medications and if they talk to you about the potential for kidney failure or kidney disease, uh well, the big take-home point is what we've talked about a bunch, and that's just stay hydrated. Yeah. And and the looks of it are that these are actually kidney protective along along with staying hydrated.

SPEAKER_01 16:20

So Okay. How about uh joint and bone health? Yeah.

SPEAKER_00 16:24

This is a new one. I mean, you you kind of brought this up to me when after I had read about it, then you brought it up first. So uh yeah, dive into the the new indications of the stuff.

SPEAKER_01 16:31

So so yeah, so the FDA has a new approval. So it's one of these things that we found out, hey, by the way, this affects so much that this is actually a a reason to prescribe the medicine, right? The FDA says that. So trzezephatite has been indicated for the treatment of osteoarthritis of the knee, and what that is, is that's that's worn-out knees. Yeah, right. So anyone over the age of 60, pretty much, or not even that, or 50. 50 or 40 in the military. Yeah. Oh, if you've ever carried a rucksack.

SPEAKER_00 16:58

Yep, yeah, you're gonna have some.

SPEAKER_01 17:00

But I mean, so there's a couple things, and again, this is one of those things that intuitively you think, well, yeah, if you are heavy, that's more wear and tear on your joints. And that's a that's a true statement. But but there's there are specific and direct anti-inflammatory effects of these medications that that go beyond just taking weight off. So both of those are benefits. I mean, if you weigh 50 pounds less, yeah, that's 50 pounds every step that you're not grinding on your knee. Yeah. Um, but there's also specific and direct anti-inflammatory effects of these medications. Um it promotes vasodilation, it reduces arterial uh stiffness, yeah, uh oxidative stress. Um, there's a clear anti-atherosclerotic effect that helps blood flow. Um, so so there's uh there's just some really good benefits of that. And and that's something you think of, oh, it makes my knees better.

SPEAKER_00 17:51

Yeah, this and this makes sense. I mean, and and me and Rick could have probably told you that we knew that there was an effect here. I mean, patients talking about um their joints ache less. I in fact, I had a patient that that that lost all their weight on a GLP one. They they got off the they would say, Hey, I want to see if I can maintain on my own. No worries, I support that. Uh they they actually ended up rescheduling about six months later, and and uh I you know, I'm figuring, hey, they must have started gaining weight again, they wanted to get going on this again. And actually, what the conversation was was, hey, I've only gained about five pounds back, I'm actually doing pretty good. They're like, I actually want to get back on because I did not realize how much my joints were aching um uh, you know, in the morning. And then when I was on the medication, that completely went away. And I got off the medication and my joints started aching again, just kind of achy, just kind of like that, you know. I just have lived a uh uh tough, you know, ongoing life. And and they're like, I get on this GLP one. So it's interesting, they would just wanted to go on a low dose to not only maintain their weight, they thought that was going to be a great benefit as well, make it a little easier on that from, but really they got back on it for uh achy joints.

SPEAKER_01 18:55

Achey joints. Well, in any, in any um, you know, some of these other studies in the Durham Journal of Medicine talks about this, uh, the neosteoarthritis one. Uh, but but there's other similar studies that have been shown. And and one of the things, like, for example, um patients with psoriasis have been shown approval. So, really, the the thinking is any any of these chronic inflammatory conditions uh seem to be uh improved. Yeah.

SPEAKER_00 19:19

Um, we've seen some of these autoimmune diseases that uh tend to run rampant. The, you know, once again, this is more anecdotal. There are some studies starting to come out about this, so I don't want to overstate it. Uh, it's more, once again, just observational in clinic, but it's at the end of the day, seeing some of these autoimmune uh diseases, um, you know, I've seen some people with Hashimoto's and things like that that were on thyroid medications and they just couldn't get it under control. They get on a GLP one, and next thing you know, they're like, look, I just stopped my thyroid medication, my thyroid's been doing great. And actually, I just I'm not having any of the effects I was having before of Hashimoto's. So, I mean, once again, I'm not claiming that that this is a fix for that. What I am saying is that like you when you start to see something in clinic over and over and over again, the studies are going to follow. Like, we will see a study on autoimmune disease and the effects on that. And I mean, for anyone that lives with an autoimmune disease or knows someone with one, I mean, boy, these can be debilitating, lifelong, horrible diseases. If you think you can get a little bit of help with that, beyond these um biologics that are brutal to the uh not only they're brutal on the pocketbook, you think the GLP ones are expensive. Go look up the biologics that are used in these autoimmune. Um, they tank your immune system, they do all kinds of things. To think that they could get some help uh with a GLP one. Um I I mean it it's it's it's it's exciting to see that.

SPEAKER_01 20:39

Yeah, 100%. Okay. Uh let's uh move forward to psychiatric disorders, yeah, addiction and psychiatric disorders. So you've talked about before, you've mentioned about like like the equivalent of a low-dose um antidepressant medication.

SPEAKER_00 20:56

There's a lot of studies that would support that. And I think we were reading one earlier, but it was uh that actually some people are finding that this uh the the mood lift, right? We know it works on uh the dopamine, the GLP ones work on the dopamine uh a little bit in the brain. So, you know, anytime you you're messing with dopamine, you know, you can have effects. Now, I think that we should um to be totally objective on this, it it's hopefully it's good, right? Hopefully it's a lift, hopefully it helps with um with uh you know what whether it's uh some mild depression or anxiety or whatnot. Now that means that anytime you can adjust dopamine, that means that it could down regulate or down shift the dopamine a little bit. And uh, so you could obviously worsen depression. Um, but the studies so far are showing a more positive benefit than a negative.

SPEAKER_01 21:45

Yeah.

SPEAKER_00 21:45

They anytime you're losing weight, you can have a you can actually have some depression. Uh most they find most people actually lose weight and feel better and mentally things are better, but um, but but there are a small uh amount of the population that actually tend to have.

SPEAKER_01 22:00

a more depressive effect with their body changing with losing weight we're not a hundred percent sure and hitting on those dopamergic um you know receptors in the in the brain that can affect mood and we're what we're seeing so far i i think is mostly positive yeah well and so you talk about dopamine so the gLP1 medications they modulate the brain's dopaminergic reward system so that's how that's how like a lot of drugs work yeah right is is they they work on that dopamine in the brain and and so what happens is the GLP1s directly affect that system there by reducing cravings for addictive substances such as alcohol and drugs yeah right so so there's been studies that have shown some semaglutide uh leading to a lower incidence of alcohol abuse or relapse in individuals with alcohol dependence uh and that's likely due to a a reduction of positive reinforcement of that whole the whole system so so that's sparked interest in treating all kinds of other disorders you know potential I mean that that that's how now other questions are being asked like hey we've got to do a study on on other psychiatric disorders on mood disorders on depression because because we're seeing this direct effect that that is showing uh how how for example alcohol abuse is decreased relapse and and and and things like that and I've seen this in clinic I mean it's it's definitely something that uh kind of surprised me initially when prescribing GLP1s it was not an effect I was expecting I was expect uh uh expect expecting an effect on obviously cravings and and appetite as it relates to food um what I wasn't expecting is how much it affected people on alcohol you know people that you know told me hey look I just wasn't straight up with you when I first met with you I told you I had uh you know a couple social drinks a week and it actually was like every night and I was drinking not one bottle but two and they're losing weight and they're having success and actually the thing that that they're most excited about short of all that is they're like and look I I don't want to drink anymore I'll geez I'll have I'll pour a half a glass of wine and I might get a few sips in and I'm just I'm just kind of uninterested.

SPEAKER_00 24:04

And when you see that and then you see that like they're losing weight which is probably in large part to due to them um not drinking as much alcohol that's going to be a big one. Yeah but also just the fact that they feel like they actually have a choice in this like anyone that's you know ever dealt with addiction I mean that that they feel like they actually feel like they have a little bit more control back in their lives. I do think the studies for this are going to be coming. I think they're gonna be I think there's going to be a lot of them I think you'll have GLP ones that are specifically targeted for this group of people that want to work on addiction whether it be drugs or alcohol because we know those effects I think it's going to be really really awesome.

SPEAKER_01 24:41

Yeah. Well there's other studies too looking at the the effects on the brain and then probably looking more in the long term but there's also quite a a bit of suggestion at this point or speculation that things uh neuroinflammatory disorders like like uh Parkinson's disease or Alzheimer's disease um may be affected there's actually some some phase three clinical trials that are looking at the effects of uh on these types of things that reduce the plax and Alzheimer's disease, improve cognitive function, um they protect the dopaminergic neurons in Parkinson's disease. So so a lot of these kind of chronic degenerative uh neurologic conditions that we associate with aging frequently I mean that and that those studies may take a long time. But anyway I am I am not going to be surprised if in 20 years we we some of these studies that are underway are going to say you know what we have really found a reduction in the risk of developing Alzheimer's or developing Parkinson's disease or worsening those conditions. It's just it's fascinating how much this affects that.

SPEAKER_00 25:38

It is yeah we we know that uh and we know even you know obviously not fully always understanding the direct effect of medications on those things. I mean we know just simply losing weight um getting your insulin uh under better control insulin sugars under better control I mean are going to affect it just let's pretend for a moment that the medication itself had no direct effect on these things but you just were able to like lose some weight and and have all these indirect effects of like getting your sugars and insulin and and all that stuff under control. We already know that those are going to have a positive effect on the kidneys and the heart and the brain. And I mean there's already a bunch of studies that support that. So you could almost make these claims beforehand knowing just the effects it has on the body. But now we're just finding all these additional things that I don't I don't want to say were totally unexpected, but kind of unexpected. We just thought that it was going to be more about initially getting diabetes and insulin under control as well as um you know maybe some weight loss benefits because everyone in the studies lost weight.

SPEAKER_01 26:36

Right.

SPEAKER_00 26:37

And so we kind of knew that that was going to happen and now it's it's just turning into so much more than that. And that's why we wanted to discuss it.

SPEAKER_01 26:43

Yeah ton of benefit. Great yeah I think it's I think it's fascinating and and just so much potential yet to be discovered.

SPEAKER_00 26:51

Yeah. So we there's all a bunch of other subjects that we'll go into with this. I mean there's uh there's always going to be emerging data and like I said Rick has a whole laptop full of hundreds of studies that we always like to look at the science and see where where things are going. But it's um they these are just some of the main benefits that that they're coming up with now in the really long but short uh time this medication has been around it's been around we know we talked with Cliff it's been around for a while um but but we do know that it's it's just more at the forefront now because as these GLP1s have changed over time and they're finding that oh hey if we move this chain over here and or the tail over here then you know it can extend the half-life and do all these cool things that we weren't expecting. So as these uh medications evolve and as they frankly get better, they're gonna find that they can have more benefits with less side effects. I think we're just gonna see more and more studies that support um even people that are not overweight using maybe even microdosing these medications for a host of other things. Yep anti all the anti-aging kind of fad right now of like everyone trying to live longer and be healthier never age another day in my life. Yeah I don't know if I want to live to 120. That just doesn't even sound fun. I guess we could transition and talk about uh the vitamin we all we always like to do a vitamin or supplement of the of the week just to talk about something. Yeah. Okay so this one.

SPEAKER_01 28:19

So so um when you know Greg and I started kind of brainstorming and deciding we want to do this we came up with you know we wanted to provide some some supplements that we we believed in and that we thought would be helpful. And so we kind of put together sourced some stuff and we kind of have our brand the weightwise nutritional supplements and that can be getweightwise.com welcome to go there buy stuff get it we think it's good stuff um if you've got some that works great that's awesome too but I wanted to talk about this one this one today just hit home the the hair skin and nails essential and this is a mix of of like vitamin A, D, E, C, uh a bunch of B vitamins and then some other you know interesting uh stuff but it it it's anyway the design hair, skin and nails essentials this is like for hair and nail growth okay so so this came out when we were kind of putting together um what we thought would be helpful to have as a as a selection of nutritional supplements we want a multivitamin with this the other my wife actually was the one she's like you need something for fingernails and hair yeah um you know she's been on a B GLP one she's like my hair's getting thin I'm menopausal age and my nails keep breaking and then the nails were driving her nuts. She'd go get her nails done and then like the the acrylic or well I don't know whatever they do fall off or break and she's like my nails are just they're too weak I can't hold this stuff and it was frustrating her to no end. So she's like I need hair skin and nails so we have the hair skin and nails and so I'm like well take it try it you know try it so she's been doing that for for a long time and um and just this morning I I uh I was getting ready and I had this bottle and she says oh because I'll tell you why it's because we are um it looks like we've sourced uh uh a way to have a the hair skin and nails we have it in a capsule but we actually we're gonna come out uh shortly with a gummy with a gummy a gummy version of that some people just don't like taking capsules so we were like hey let's get them a gummy so we're trying to find you know some of them we had a gummy multivitamin or we're trying to resource that because it it kind of petered out so we we want to have a good source for that yeah so we're working on that but but we do have um an upcoming hair skin and nails gummy as well same kind of thing just just in a gummy form so I mentioned that to my she's she's works crazy honestly she's I've been taking this and it's just I feel like I need to get my nails done more frequently because they're growing so fast.

SPEAKER_00 30:35

Yeah like like they're stronger they're growing like it's it it was I was like really she's like yeah it's still working like a channel I hear it in clinic all the time actually the probably the number one I hear from men but I hear it a little bit more on the women's side especially women getting into that perimenopausal or even postmenopausal state like because already naturally our bodies are like you know the the nails are going to get more brittle the skin's not going to be quite as robust and and um you know those cells don't replicate as quick and then hair right like women's hair thinning um it happens naturally it amplifies with weight loss and it not for everyone some people do just fine other people when they lose weight unfortunately your body kind of you know you're in a calorie deficit and so that's why we wanted the supplements because as Rick coined a long time ago we want you in a calorie deficit not a nutritional deficit. So sometimes you just when you take down calories sometimes you're just not getting all the nutrients you need so we wanted to have this one and and the reason why is because in clinic all the time I hear my hair is thinner my um my nails are getting more brittle things like that. So they're loving the weight loss but they're not loving some of these uh effects from that weight loss can have and so I hear it all the time now that we've had this out long enough and I've had several people uh try it you know the uh just a patient yesterday hey I have all these new little frillies um new growth yeah new growth they're they're like yeah and so I'm like they ended up purchasing more um and getting going on that and they're just saying they wanted to stay so I know I know had I only had I only known about had I only known about 20 years ago um yeah so DB it's amazing though I mean I mean again this isn't the not a study like we've been talking about that it this is like anecdotal stuff like people that we know have done this have said hey this really is amazing it's helping me a ton and there's a lot of products out there there's tons of hair skin and nail products the thing is is that like even the I'm not gonna mention their name because I don't know if I can but uh there's a really popular one but they're I mean you're spending 200 bucks or 300 bucks for a for a three month supply um and and it's a fantastic product but three hundred dollars uh you're not gonna spend anywhere near that on our website for this and uh especially if it works yeah and you know frankly it has a lot of the same ingredients so um the the truth is is that um any of your supplements like we can't necessarily stamp our medical endorsement on them we can just take what's available out there and try to just put together uh as good of a supplement list as we can yeah so yeah get weight wise get a nail yeah getweightwise.com we have we have if you're like I'm not sure what to take like I'm not sure what to take we made bundles so if you're on a GLP one already and you're losing weight you can go on there and get the GLP one bundle of what we recommend there. Um or if you or if you're just uh looking to optimize your wet women's or men's health like um to help with hormones and just help with all that I mean we have these bundles that we already built on there that says hey look these are kind of the these are kind of the four three or four things that we would recommend in that situation. Right. So and yeah and you're not gonna you know you're not gonna spend your entire monthly earnings on supplements because we don't really think that that's the answer there. We think you know just a good supplement supplement solid supplement yeah so yeah I think that's a good one to to bring up it has a lot of the stuff um biotin and and other things that are so important for good hair skin and nails so um yeah I I'm glad that uh I'm glad that we're seeing the effects of that okay so we even have I can't even read this stuff it's so small but I mean there's actually some proprietary things on here um about uh P aminobenzalic acid and bamboo extract and stingy nettle and like there's there's there's some plants there I mean there's there's there's some some smaller ingredients on here that I don't know if that's what's making it work but it's been a fabulous thing for for several people that we know. So yeah we really like that one.

SPEAKER_01 34:24

So that is your uh vitamin or supplement of the week yeah if you're if you're dealing with that whether it's from weight loss or just naturally from aging uh we do find that that this one in particular this this kind of formulation has been really effective so go pick yourself up some yep getweightwise com and uh you tune into our episodes you can get us on our YouTube channel uh at uh support my weight loss or at supportmyweightloss.com there's a live stream page with a link to all of our previous uh videos yeah uh and we're gonna get some more stuff on here soon uh but I think that's good for tonight uh remember a uh advice and relationship with your medical care provider is always recommended prior to starting any supplements or weight loss program or medications. Um our information here is educational informational only not intended as medical advice uh with that we'll uh tune out and uh talk to you next week.

SPEAKER_00 35:19

Yep see you then