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Causes or Cures
For the Nerds and the Nerd Nots
Causes or Cures is an independent health podcast hosted by "Dr. Eeks" (ErinKate Stair, MD, MPH). It is an offbeat, grassroots show driven by curiosity and a genuine love of making complicated health topics easier to understand.
Dr. Eeks is a public health professional specializing in applied epidemiology & health communication. By day, she works on challenging public health issues. By choice, she spends some of her free time asking scientists, physicians, researchers, authors, clinicians, and other fascinating people questions she hopes everyone else is wondering too.
Along the way, the podcast has wandered into everything from memory and longevity to self medicating animals, migraines, gene drive mosquitoes, strange public health history, the spiritual realm, and the occasional existential detour. If it has something to teach us about health or what it means to be human, it is probably fair game.
Recurring segments include Public Health is Weird, which uncovers strange but true stories from public health history, WTF Health News, where Dr. Eeks breaks down bizarre or buzzworthy health headlines, and Eeks Speakeasy, a more personal corner of the podcast where curiosity occasionally spills over into life, philosophy, and whatever else deserves a drink and a discussion.
A few housekeeping notes...
This podcast is for information, curiosity, and conversation. It is not medical advice.
Although Dr. Eeks has an MD, she does not practice medicine. She is a full time public health nerd and will never tell you what to do with your own health. If you have a medical question, your healthcare provider knows you far better than a podcast ever could.
Guests are invited because they have something interesting to contribute, not because Dr. Eeks agrees with every opinion they hold. Likewise, she does not endorse miracle supplements, mysterious oils, magic socks, potions, or anything that promises to solve all of life's problems.
If an episode is sponsored or underwritten by a company she genuinely enjoys working with, she will always tell you.
Causes or Cures is also not a news site. It is a place for thoughtful conversations. Dr. Eeks believes people can disagree respectfully, ask difficult questions, change their minds, and occasionally laugh at themselves along the way. Some of the best conversations she has ever had happened in hole in the walls, on sidewalks, and in places where nobody was trying to win an argument.
Sometimes Barnaby, her dog and unofficial executive producer, contributes his thoughts as well. Fortunately, he is a pretty smart dog.
Above all, Dr. Eeks hopes this podcast encourages people to stay curious, compassionate, honest, open minded, and engaged. Freedom of discussion is a beautiful, delightfully messy thing, and one worth protecting.
The views expressed on this podcast are Dr. Eeks' own and do not reflect the views of any organization she contracts with or consults for.
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Want to sponsor or underwrite an episode?
Causes or Cures works with a limited number of sponsors and episode underwriters in health, science, and public health. Partnerships are kept separate from editorial content and guest selection. If your organization might be a fit, reach out at: erin@bloomingwellness.com
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Causes or Cures
They Received an Experimental Vaccine for Advanced Breast Cancer Decades Ago. They’re Still Alive Today—Dr. Zachary Hartman on the Science
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What if cancer didn’t have to be eradicated, but could be remembered, monitored, and controlled by the immune system itself?
In this episode of Causes or Cures, Dr. Eeks speaks with Dr. Zachary Hartman, the lead researcher who revisited an extraordinary breast cancer vaccine trial conducted over 20 years ago. The trial involved a small group of women with advanced breast cancer. Women who, remarkably, are all still alive today.
By analyzing their blood decades later, the research team discovered that these women still carried immune cells capable of recognizing their cancer, suggesting durable immune memory lasting more than two decades. (Study link here.)
We discuss:
- The original breast cancer vaccine trial and what it was designed to do, in plain language
- What it was like to discover that the women from the trial were still alive more than 20 years later
- How the immune systems of these women continued to recognize cancer cells long after the trial
- What CD27-positive immune cells are and why they matter, explained simply
- Why helper CD4 T cells may be just as important, or more important, than killer CD8 T cells when it comes to cancer
- What happened when researchers combined a CD27-boosting antibody with a cancer vaccine in mice
- What surprised the research team most
- The challenges of translating findings from mice to human trials
- Whether cancer could someday be managed long-term by the immune system
- How generalizable this immune memory might be across different cancers
- What this research could mean for how we think about vaccines in a post-pandemic world
- The one key message the researcher hopes the public takes away
- What’s next in this line of research
Guest Bio: Dr. Zachary C. Hartman is an Associate Professor at Duke University in the Departments of Surgery, Pathology, and Integrative Immunobiology, where he also serves as Director of the Center for Applied Therapeutics and is a member of the Cellular and Molecular Biology and Genetics and Genomics programs. He earned his undergraduate degree from Northwestern University and completed his PhD at Duke University, followed by postdoctoral training in tumor immunology and breast oncology at Duke and the MD Anderson Cancer Center. In 2012, Dr. Hartman returned to Duke to establish a research program focused on tumor immunology and the development of cancer immunotherapies, including therapeutic vaccines, immune agonists, checkpoint inhibitors, antibody-based therapies, and strategies to stimulate anti-tumor immune responses.
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