This One Time On Psychedelics
Welcome, fellow explorers of the infinite.
If you’re here, it means you’re ready to step beyond the ordinary and into the great unfolding mystery of existence itself. Because psychedelics? They’re not just substances—they’re a doorway to a new way of seeing reality, a lens that reveals the hidden layers of reality we walk through every day. And that’s exactly what we explore here.
I’m Ryan Sprague, and This One Time On Psychedelics isn’t just about trippy stories and wild journeys (though trust me, we have plenty of those). It’s about the conversations that hold the power to awaken us, to shift our consciousness, and to remind us that there is far more to this reality than meets the eye.
These are the conversations that expand hearts, challenge perspectives, and guide us back to the wisdom that has always been within us. Whether through plant medicines, altered states, or the everyday magic woven into life itself, this is a space where we step beyond the known and into the infinite.
The psychedelic renaissance is here. The future is unwritten. And you, my friend, are a part of it.
So buy the ticket. Take the ride. And let’s see how deep this trip goes.
Episodes
213 episodes
Ep. 213: It’s Not Goodbye, It’s See Ya Later! (feat. Rachel Varitimos)
Alrighty guys, this episode is extra special to my heart because it’s officially my last episode (for now) on this show before I transition back to the Highly Optimized podcast, my first project that was birthed in 2019 when I chose to start...
Ep. 212: The Trifecta Of MDMA, Psilocybin & Intramuscular Ketamine (feat. Adam Schell)
One of the main reasons I started this podcast was to showcase the stories, experiences & impact these medicines have made upon people’s lives. That being said, I still get goosebumps when I hear those stories as they remind me of the im...
Ep. 211: Adventures In Decentralization & Why This Movement Excites Me SO Much (feat. Amethyst Flame)
For anyone with eyes to see, it’s no secret the world is changing at a rapid rate these days. From political hysteria, to new technology emerging almost daily, it’s safe to say that it’s easier than ever to feel overwhelmed while simultaneou...
Ep 210: How The 2018 Farm Bill *Accidentally* Legalized Cannabis (feat. Rand Gifford)
Every episode I do I am excited about, however, this one holds a special place in my heart for a few reasons. First, anytime I get to speak with someone who is as passionate as I am around regenerative agriculture, I geek out like a small sc...
Ep. 209: An In Depth Look At How Astrology Has Changed My Life (feat. Rachel Varitimos)
Whenever I have the opportunity to do a podcast with the love of my life, I jump at the opportunity & this week’s episode is no different. Many of you love the episodes here & I do together & our intention with todays episode is ...
Ep. 208: Psychedelic Experiences, Presence & What Really Matters In Life (feat. Seibo Shen)
One of the main reasons I love podcasting so much is, yep, you guessed it, I adore speaking, however, speaking to myself alone in a room is a little weird & definitely not the same experience as when I get to speak to others who stimulat...
Ep. 207: You Don’t Need A Guru: Here’s How To Heal Yourself (feat. Christopher August)
Whenever today’s guest & I get together, I know it’s going to be an epic conversation. From working together the last two years creating the Breathe With Cannabis brand that many of you have attended already, to traveling to epic places ...
Ep. 206: Opening Up To A Brand New World Through Psychedelic Medicines (feat. Kyle Langan)
One of, if not my favorite types of stories I enjoy hearing from the psychedelic space are the stories that come from individuals who, at one point, did not resonate with psychedelic medicines at all. You guys have heard me say before & ...
Ep. 205: The Mysteries Of 12 Strand DNA Decoded (feat. Dr. Samuel Lee)
I am sure you guys know what I mean when I say that sometimes I find someone new out there in the world & just cannot get enough of their content & perspective of the world. For me, I take these types of experiences as signs. Signs t...
Ep. 204: Utilizing Psychedelics In The Grieving Process To Heal (feat. Mia Cosco)
One of the areas within the psychedelic space that is extremely important, yet often overlooked, is the ability for these medicines to assist in the process of grief. Grief is something that all of us, no matter what background, ethnicity or...
Ep 203: Demystifying The World Of Ayurveda (feat. Ivette Desai)
Chances are this isn’t the first time you’re hearing the term “Ayurveda”. For those of us who identify as spiritual seekers, the world of ayurveda is one we hear of often & already practice to some degree in our lives (where my shilajit lov...
Ep. 202: Exploring Quantum Shifts & Synchronistic Moments (feat. Shawna Pelton)
Sometimes in life, I meet people that just feel like a breath of fresh air in my life. It’s hard to put into words what I mean by that, but for those of you who have experienced this notion, I imagine you know exactly what I mean & today...
Ep. 201: Journeys In Psil-osophy, Hermetics & Psychedelica (feat. Austin West)
As you guys may have heard on my episode 200 solo cast last week, my favorite part of this podcast is meeting individuals that once I meet, I truly have no idea how I’ve gone my whole life not knowing. The truth is that the relationships in ...
Ep. 200: What A Journey It’s Been…
Wow guys…what a journey it’s been. It’s hard to believe that this podcast is already at episode 200, but, like they say, time flies when you’re having fun. In this episode, I decided to do something I’ve only done once before & do a solo...
Episode 199: The Psychedelic Frontier: Navigating Entrepreneurship & Safety (feat. Matthew Ritchey)
The emerging world of psychedelic medicines, accompanied by the ancillary industries associated with them, is bringing with it a LOT of opportunities. For me, being as how I grew up in the world not generally interested in most of what other pe...
Ep. 198: Opening Up To More Magic & Purpose Through Psychedelic Medicines (feat. Sofiya Skakri)
Each time I have the opportunity to do a podcast with someone who fills my heart up with joy & inspires me to dig deeper into my mission I have a blast. This being said, todays guest on the show is a woman who although I only met recentl...
Ep. 197: How Psychedelics, Hypnosis & Biohacking Can Help You Create The Life Of Your Dreams (feat. Elia Bean)
For any of us that love psychedelic medicines, one thing that quickly becomes apparent is their ability to rapidly transform our mental landscape, including shifting belief systems, architecting new stories for us to live life through & ...
Ep. 196: Combining The Powers Of Cannabis & Tantra (feat. Zipporah “The High Priestess” Gongora)
I am fortunate enough in my life to be able to do what I love each day of my life & a BIG part of that is the love I have for podcasting. As such, I truly love & deeply enjoy all the episodes I get to do & have a blast connecting...
Ep. 195: How Psychedelics Can Make You A Better Entrepreneur (feat. Ani Manian)
One of the things that most people who do not utilize psychedelic medicines in their life would not immediately see a link between is how psychedelics can allow us to become better business owners & leaders, however, in my opinion, these...
Ep. 194: Tales From The Water Shaman Himself (feat. Samson “The Water Shaman” Luce)
You guys know that feeling you get when you meet someone who makes you feel more safe knowing they’re walking the planet the same time you are? This is the exact feeling I got when I originally met the guest for today’s episode. This man is ...
Ep. 193: Master Your Breath, Transform Your Life (feat. Christopher August)
If there is one modality aside from psychedelic medicines that has assisted me immensely over the last decade of my life, it is breathwork. From all the varying styles available to us to the fact that no matter who we are or where we are in ...
Ep. 192: How Psychedelics Can Help You Be A Good Steward For Planet Earth (feat. JR “The Bear” Hendry)
After many years of podcasting, coaching & otherwise talking non stop, I’ve truly come to realize, understand & appreciate the art of conversation. When I meet individuals who I can have an off the cuff, pure flow state deep dive wit...
Ep 191: From Wall Street To Psychedelics, Spirituality & More (feat. Jason Pickard)
Every once in a while in my life, I meet someone who as soon as I meet, I wonder how in the hell I ever lived my life without them in it. Typically, these people are people that I feel an instant connection with & who, along with many ot...
Ep. 190: The Complete Deep Dive Into Cannabis Genetics (feat. Joe Colletta & Patrick)
The world of Cannabis genetics today looks much different than it did even just 5 years ago. With more & more breeders coming forth & more strain selection than ever, I find many people are confused on how to navigate this world &...
Ep. 189: Finding Strength, Courage & Love Through Psychedelics & Sound Healing (feat. Shelley DeMarco)
In the current psychedelic renaissance, many people who otherwise had never been interested in psychedelic medicines are now finding interest in working with them. Whether it’s through the mainstream, the self development/spiritual industrie...