Longevity Escape Velocity with Dr. Peter Diamandis

Prepare to be inspired by our esteemed guest, Dr. Peter Diamandis, as we explore the realm of extending human lifespans through exponential technologies. His wealth of knowledge, from a background in a medical family to pushing the boundaries of space exploration, sets the stage for an episode packed with innovative ideas. We delve into the exciting world of regenerative medicine, discussing the promising future of placental derived cells and the tiny powerhouses known as exosomes. Dr. Diamandis's enthusiasm for his work is infectious, whether he's talking about dietary impacts on longevity or the critical role of NAD precursors in maintaining mitochondrial health.

This episode goes beyond the physical, examining how our mental frame can shape our biological reality. You'll hear about historical examples of how a positive outlook could lead to a longer, healthier life, affirming the notion that a future-focused mindset is a key to longevity. We'll explore the intersection of technology and wellness, considering how AI tools like Futurescope are transforming our approach to health. Discover how creating a purposeful life, avoiding the retirement trap, and engaging with companies that prioritize early intervention can revolutionize your well-being.

Finally, we open up an engaging discussion on the science of anti-aging interventions, from the benefits of NMN supplements to the power of AI in healthcare. Learn about the proactive approach of Fountain Life in disease prevention and hear about the transformative effects of fasting on cellular repair, informed by Victor Longo's research. Plus, we highlight an innovative vaccine in development targeting cardiovascular disease—a potential game-changer in preventive medicine. Join us as we navigate these pioneering advancements with Dr. Diamandis and step into a future where aging might just be an option.

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ReverseAgingRevolution Summit June 20-22, 2024 https://robertlufkinmdcom.ontralink.com/t?orid=49&opid=2

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Transcript

Speaker 1: 0:02

Welcome back to the Health Long-Givenny Secret Show, and I'm your host, dr Robert Lufkin. In today's episode, we get to unlock the secrets to a longer, healthier life with our special guest, the visionary Dr Peter Diamandis. His unique insights bridge the gap between exponential technologies and extended human lifespan, revealing a future where artificial intelligence, quantum computing and advanced biology converge. In a narrative that weaves personal passion with pioneering science, peter takes us from his roots in a medical household to the stars of space exploration, all the while focusing on the potential to add vibrant years to our lives. Explore the forefront of regenerative medicine with us, as Peter discusses innovative work with placental derived cells and exosomes. The potential for these therapies to heal, maintain muscle mass and fight age-related decay sets the stage for a healthier tomorrow. Peter's optimism and proactive stance towards medical advancements offer a refreshing perspective on the aging process, and his insights into NAD precursors and mitochondrial health underscore the exciting developments on the horizon, from intermittent fasting to the imperative of dietary choices, including the elimination of sugar, of course. This episode is packed with actionable advice and personal anecdotes that highlight the need for a tailored approach to wellness. Join us on this episode that not only envisions a brighter future, but also equips us all with the knowledge to actively shape our own healthier, extended life.

Speaker 1: 1:53

And before we begin, I wanted to share a short 30-second video that's prepared about our upcoming book, which has now has been running several weeks now at the number one bestseller status on Amazon. Thank you very much for that. Those of you who are listening on audio, you're going to hear 30 seconds of the soundtrack for this and then we'll get going from here right after that. This episode is brought to you by El Mnutra, maker of the prolonged fasting mimicking diet. If you'd like to try it, use the link in the show notes for 20% off. And now please enjoy this week's episode.

Speaker 3: 3:11

Very pleased, during this particular session, to invite Peter Diamandis to join us. Peter has been recently named as one of Fortune's 50th 50 greatest leaders. He's the founder and executive chairman of the X Prize Foundation, executive founder of Singularity University and he's the author of four New York Times bestselling books, including the most recent one, life Force, with Tony Robbins. Peter, it's such a pleasure to welcome you to our program.

Speaker 4: 3:46

Pleasure Steve, Good to be here.

Speaker 3: 3:49

Let's start by just kind of giving us a sense. I know that there's so many different areas, that cutting edge areas that you're involved in, but how did you get interested in the area of longevity?

Speaker 4: 4:02

You know I grew up in a medical family. My father was an OBGYN, my mom should have been a doctor right in his office and it was expected I'd become a doctor. I went to MIT undergrad for molecular genetics and in the nighttime I would do focus on everything related to space. I was a space junkie. Star Trek and Apollo really lit me on fire, ended up going to medical school, did a joint program at MIT and Harvard and after I got my diploma I shipped a photocopy to my parents and then when started focusing on my space journeys and started building companies in the space arena launch and satellite and zero gravity company, a space university and pursued space for 30 years. And it was about 20 years ago that I really started getting focusing in on exponential technologies, how computation sensors, networks, ai, robotics and everything going on in biotech had the potential to reinvent every industry. And, in particular, it hit me that lifespan, health span was a huge opportunity for disruption and it came.

Speaker 4: 5:11

My interest in this area came from two different places. One from my childhood desire to open up space. There's not been enough progress to make me happy. Right, we haven't seen the Star Trek, we haven't been on back to the moon or gone to Mars. So I figured okay, I need an extra 50 years on this planet to at least see the potential of what I desire to see. The second is just the grand challenge of it all, and I think there's no greater gift you can give than increased health span and no bigger business on the planet For me.

Speaker 4: 5:42

I have a half a billion dollar venture fund called Bold Capital and we had been investing mostly in exponential tech and robotics and AI, but I've shifted the fund mostly two thirds now to biotech with an age and longevity focus, because I think it's one of the biggest markets out there. So those areas. There was one pivotal moment for me, steve. When I was in medical school I watched this television show on Long Live Sea Life and it was talking about how Bowhead, wales, could live 200 years and Greenland Sharks could live 400 or 500 years, and I remember thinking if they can live that long, why can't we? And I said it's either a hardware problem or a software problem, and I think this is the decade where we start to make a dent in those problems.

Speaker 3: 6:31

Yeah, so it's a convergence of a lot of very important facts there, including your own interest in having more time here to do all of these exciting things.

Speaker 4: 6:41

Yeah, it's the most exciting time to be alive, so I want to see as much of it as I can.

Speaker 3: 6:46

Can you give us your perspective on aging, like why we age? I know you mentioned hardware, software, but what's your perspective on why?

Speaker 4: 6:54

we age? Yeah, that's a great question, and I think of it the following right, and these are the fundamental sort of baseline facts that get me thinking about aging in this way. It's you know, we're all born with 3.2 billion letters from our father and our mother and we have the same genome really throughout our lives, at birth, at 20, at 50, at 80, at 100. So why do you look different? Why do you age? Right, it's not the genes you have, it's which genes are on and which genes are off. Obviously, david Sinclair is a friend and his theory on, you know, information theory of aging for me has a lot of validity. But it's again, it's the notion of making sure that your epigenetic control of your body, of your genome, is solid. I doch on it, you know. The other thing that hits me is that when we were evolving on the savannas of Africa, 100,000 years ago, you know, during the time we call cavemen, you go into puberty at age 12 or 13. By the time you were 24, 25, 26, you were a grandparent, your babies were having babies, and Back then, before we had an abundance of food, before McDonald's and Whole Foods was around, if nature's mission was to perpetuate our species, to pass on our genome generation to generation. The last thing you wanted to do Was steal food from your grandchildren's mouth, so there was a positive bias for an early end of life. There was no selective factors to keep you alive longer, and so we evolved in that direction.

Speaker 4: 8:36

Now the question is can we go from Darwinism, evolution by natural selection, to, you know, an evolution by intelligent direction? Can we reinvent the software and hardware of our body? Can we understand the fundamentals and Along this line? This is where you know, the work that I do in studying exponential technologies really flips my mindset. The the realization is, we all inherently have a linear bias in how we think we expect Tomorrow and next year to be very much like this year a little bit of progression, maybe not too much, but the fact is and I think this is the work that my colleague and mentor, ray Kurzweil, has spoken about we're gonna see in the next decade as much progress as we've seen in the past century.

Speaker 4: 9:28

That's how fast technology is accelerating, and so I think that we're gonna see a disproportionate application of artificial intelligence and what's coming just after that that's going to make AI look like it's standing still, which is quantum technologies, quantum computations, sensors and communications, I Enable an understanding of biology which I think at its basis, you know molecular in nature, is quantum in nature. We're gonna start to understand fundamentals there and I think we're going to start adding additional healthy years into our life. And that brings about what what Ray and Aubrey de Grey have spoken about as longevity escape velocity the notion that there's going to be a moment in time that for every year that you're alive, science is adding more than a year to your life.

Speaker 4: 10:23

By an interviewed Ray and George Church for my book that I did with Tony Life Force and and I asked Ray when do you think we're gonna reach longevity escape velocity? And now, ray is not a biologist but he is a technologist and has one of the most accurate predictions Out there. It's, if you Google his name and predictions, it's like 84% accuracy. And his prediction on when we'll reach longevity escape velocity is the next 10 to 12 years. I, when I asked George, I expected him to be a lot more Conservative and he was, but not by much. You know. It's like 15 to 20 years. So our job here isn't to live an extra 50 years, it's to live long enough to intercept the new technologies coming in the next 10 to 20 years right, right.

Speaker 3: 11:12

Well, that's, we're very close then, based on both of their predictions. Yeah, there are a couple of directions. I'd like to go with just the first response that you gave me, but one of the things that I know is very important in your perspective is mindset. I I wrote an article recently on purpose, which I did, I said, is the ultimate and use it and loo or lose it, and you talk about mindset as being very important. How does mindset Impact longevity in your opinion, and what would be the mechanism that that happens in that process?

Speaker 4: 11:55

sure. So there's a there's a quote I use from a dear friend, dan Sullivan. He goes Need to make sure that your future is bigger than your past. Right, and that's a very simple but very big idea that if you're, if you feel like, listen, I've lived my life, there's nothing more to look forward to. It's done. You know, if you look at the research, you can effectively will yourself to death.

Speaker 4: 12:22

And we all know situations where you know one Spouse dies and then a few days later or a few weeks later, the second spouse dies. You know, and that was not predetermined at birth, it was an impact of losing someone that's that close to you. So there is a physiological connection between mind and body. There's also a connection of you know, if you're excited about, about life, if you're Vibrant, you know, keeping your mind engaged and your body engaged. All of these things have secondary and tertiary benefits.

Speaker 4: 12:56

One of my favorite stories has to do with the founding fathers of our of our country. I'm trying to remember which two founding fathers it was was, I think was Benjamin Franklin, and I'm blanking on the second who. They both lived exactly to the 50th anniversary of 1776 July 4th 1776 and died on that day. They lived to see the 50th anniversary of the nation that they had started. And again, is that random? I don't think so. I think it's like having something to look forward to that keeps you alive. So I think mindset is very important. I think of you know, today, before we have epigenetic reprogramming and gene therapies and stem cell, you know, restoration and all the Sinalika medicines out there, before we have that, we have the basics for Extending the healthy lifespan. Right, it's diet, exercise, sleep, mindset and not dying from something stupid, which I can talk about in a second. But in the mindset you have to believe that in fact there are breakthroughs coming, that the technologies to extend your lifespan are on the horizon, that you have something to look forward to so that you have less inflammation, less aches and pains, less you know, you know low energy days.

Speaker 4: 14:18

And one of the things I did, steve, was I built An AI called called Futurescope that searches the world information for and use on any subjects that's, the information for high scientific validity, and then creates a summary of the article with an appropriate image. So I set it free and and and built something called longevity insiderorg. So every day I get the top 10 breakthroughs in the field of longevity and I read and it's like, oh my god, that's amazing, I had no idea. Because I had no idea, oh my god, that's amazing, I had no idea, because you know, we never see this in I in the news media today, unless you're actively looking for it. So longevity insiderorg is free For me. It's how I maintain my longevity mindset, because I'm seeing every day the progress being made on all of these technology fronts.

Speaker 3: 15:17

I can think of two different ways that mindset may play a role here. One is that it sends some kind of direct message to our epigenome.

Speaker 4: 15:29

Yes.

Speaker 3: 15:29

That actually makes some changes there. The other is simply that with a positive, healthy mindset, the body functions more efficiently, more effectively and therefore it ages more slowly. Do you see those as two separate processes, or you know?

Speaker 4: 15:51

I won't venture to guess, but I also think there's a third process, which is, if you're excited about what you're doing, you're going to get out of bed earlier, you're going to want to feel better, you're going to learn. Of course, we all know that brain plasticity is a real thing, that you do when you learn, when you and Robert put on this event and you're engaging and you're learning and you're talking. That is really driving you forward, instead of waking up in the morning and deciding whether you're going to make a cup of coffee or not. So I mean, there is, you know, one of the challenges is this four letter word spelled retirement. You know it's. People retire and lose their will to do anything, and I think retirement is a bad idea for anybody. There's a correlation between when you retire and when you, you know, pass away. I think retirement is the equivalent, mentally, of telling the universe OK, I'm done making use of my body, it's time to give it back to the ecosystem.

Speaker 3: 17:01

Right, right and yes, and I would agree that a positive mindset does drive healthier behaviors. So I would certainly agree with that. Back to your analogy to the caveman and 100,000 years ago and how we lived, into just our 20s or 30s, and we have the evolutionary sort of baggage or legacy of that in terms of many of our enzymes, hormones beginning to drop off around that age.

Speaker 4: 17:38

Yes, exactly.

Speaker 3: 17:39

What's your feeling about replacement therapies to replace those decreasing substances?

Speaker 4: 17:48

Yeah, I think that it is important to try and get us to homeostasis again, get us back to baseline. So I do testosterone supplementation, I use a peptide to boost my IGF-1 levels and a variety of things. I won't go into a list of them here, but I had the chance to start two companies one called Fountain Life that we can talk about. That really is a diagnostic side of the equation, a therapeutic side of the equation. On therapeutic side it really is about how do we bring you back to hormone optimization versus just supplementation? Where should you be? And then another company I'd started with Tony Robbins called Lifeforce. That is similarly, with peptides, medicines, hormones, really trying to get you back to a baseline. So do I believe that we need to supplement what we have? Absolutely.

Speaker 4: 18:52

Also a big believer in the power to restore our stem cell populations, our regenerative engine of our body. It's not legal in the United States other than your own stem cells from fat or bone marrow, but the research will get done. One of the companies I co-founded with Bob Hurrie, who's the chairman CEO of Cellularity I serve as the co-founder and vice chairman is the largest placental facility out there. We have stored hundreds of thousands of placendas. We desolularize those to bring out the natural killer cells, the T cells, the stem cells and the exosomes that are then really developed as cellular medicines to address everything from immune function to sarcopenia to wound healing, to really the natural killer cells being used to fight a number of different cancers in clinical trials today.

Speaker 3: 19:54

You mentioned in that comment exosomes. What's your opinion on their value in terms of longevity?

Speaker 4: 20:03

So I think exosomes again are in the gray zone from the perspective of the FDA today. I think that we need to give those companies support to produce those, because I think there is value for them. I have used exosomes myself in terms of accelerating wound healing, post-surgical, and I think that this is really giving your body the growth signals and repair signals that it might have done in your 20s but in your 50s, 60s, 70s, no longer has the capability to provide. So a lot of research still to be done, a lot of work under IRBs and INDs, but I think these are incredibly important tools. There's a company I'm an advisor and an investor to called Immunis.

Speaker 4: 20:58

That has been really is in human clinical trials right now, taking the exudate of stem cells really all of the growth factors and the exosomes and using that as a mechanism to stimulate and maintain muscle mass. And I think most everybody here will know muscle mass is one of the critical factors for longevity. There's a direct correlation between your muscle mass, and so I'm fighting sarcopenia every day. I'm 61 and I work out. I've increased my protein intake to handle it, but I would love any other technologies that allow me to maintain a significant level of muscle.

Speaker 3: 21:44

So these approaches that you're just describing, including stem cells, et cetera, what's the time frame in terms of when they might be fully available?

Speaker 4: 21:57

So they are available outside the United States today. So we don't at Fountain Life and the therapeutic side, we don't provide stem cells domestically today we send people. We've vetted six or seven different stem cell clinics outside the US and the Caribbean Mexico, panama, costa Rica, other locations and we sent our members to the Regenerative Medicine Institute in Costa Rica, dr Vince G and Papa there, just because the level of service and the science there, we think, is very high. We've been looking with a cellularity to implement an IND to look at placental derived stem cells. So we're going to see this over the next increasing in capability but under really critically vetted scientific measures and data collection. We need to collect the data to make sure that it is safe and efficacious, under what conditions it is so.

Speaker 4: 23:09

So I think that's this decade. But stem cell exhaustion is definitively one of the hallmarks of aging. If you look at stem cell populations in a newborn compared to someone in my age, in every different segment of tissues we've seen stem cell reduction by a factor of 100 to 1,000 fold and that's challenging, challenging in your ability to repair and challenging in your ability to maintain functionality and vitality of those tissues and organs.

Speaker 3: 23:45

Yeah, yeah. And so like Back to some of these supplements, for example NAD, which is so important to the health of our mitochondria. What's your opinion in terms of when you take these supplements? Do you believe they're actually going to where? They have an impact.

Speaker 4: 24:07

So NAD obviously is not a supplement. It is the powerhouse inside the cell right, the precursor. You know there's no carrier molecule for NAD to get across the cell membrane that we know right now and the precursors are NMN and NR, and I do take about a gram of NMN every day. Is it? Do I feel a physiological difference from that? Maybe, but I think it's more based on belief than anything else. And there is good science data in animal studies today, not human studies.

Speaker 4: 24:48

There is a study going on right now by a company called Metro Biotech, run by a friend of mine, which is doing a study with the US Special Forces, and they have a very purified form of NMN called MIB626 that they're looking at and they're providing under a clinical study, under a double blind study with Special Forces, looking at increased muscle strength and cognitive capability, and the early study results were very positive and we'll see where that plays out over the next few years. So am I excited? Yes, Do I think we really hit the knee of the curve yet? No, I think we're going to see massive data sets being analyzed by AI in the next one to four years and then quantum technologies really making a huge dent in this in the next four to six years.

Speaker 4: 25:54

That's quite quite something else for us to look forward to it is, and I think having something to look forward to is part of that mindset element.

Speaker 3: 26:04

Yeah, yeah, and so what other mechanisms do you think are out there in terms of our ability to slow or reverse epigenetic aging?

Speaker 4: 26:16

Well, there's one thing which is important, and you may have someone from Fountain Life speaking as well. It's a company I serve as executive chairman of, and co-founded with, tony Robbins and Mark Benioff, and Fountain Life has built these 10,000 square foot diagnostic centers where we do full body MRI, brain brain imaging, brain vasculature and AI, coronary CT, dexascan, genomics, 150 gigabits of data, and the reality is we are always in a state of some level of degradation, degeneration, as you said. After 30, our thymus starts shrinking, our hormonal levels start going down, our growth hormone levels start going down, and so we're in a slow decline. And the other thing going on is that we start to develop diseases that were never pre-selected against, because you had reproduced by the age of 30. And so these diseases would occur later on in life, and we're all developing cancers all the time. Hopefully, our immune system, our natural killer cells, are finding those cancers and zapping them, but there's another thing called immunoxasin. As we get viral burdens in our body, our NK cells are focused on viruses and not cancers, and that's a challenge. So one of the things that we do at Fountain Life is we do an annual upload where you're fully digitized, and then quarterly additional testing and the goal is to find disease at inception and zap it at the beginning.

Speaker 4: 27:56

Our bodies are incredibly good at hiding problems. You know you don't feel a cancer at stage one or stage two. You experience at stage three or stage four, many times when it's too late. Right For Parkinson's, you don't really have the tremor until like 70% of the neurons are gone and your body compensates for all these things and unless you're looking, you do not know. So in our first, I think, like 45,000 patients going through all this testing, our members going through this testing, we've discovered 2% have a cancer they don't know about. 2.5% have an aneurysm they don't know about. 14.4% have a significant finding that is, could impact their lifespan, that they need to know about.

Speaker 4: 28:43

And so I call this category of not dying from something stupid, in other words, looking and understanding and then when you find something, taking action right away. You know in, like in the wildfire world, do you want to try and put out the wildfire after it's a conflagration or at the first spark? Right? And the same thing here. You know you're going to find out eventually. When do you want to know the beginning or later? So that's what we built with fountain life. We also built an insurance company called fountain health insurance, which I'm very proud of, where, for your current health insurance for self insured company at 1000 bucks a month, we give your employees all of the testing for free. So the health insurance instead of paying you after you're sick and have had your surgery. The goal of the health insurance is to keep you from getting sick in the first place. So, again, there are lots of things that can be done in that regard.

Speaker 3: 29:45

Yeah, I think it's so important to get baseline yes, that measures, and then, as you continue to take measures, perhaps every year, it's not only looking at you compared to the normal, it's also you compared to where you were a year ago, so that you actually pick up on changes that may not be appropriate.

Speaker 4: 30:11

Exactly I. First time I did a full body MRI, I discovered I had an enlarged aortic root and it was like, is that me or is there something going on? And it hasn't changed in eight years. And so it's my baseline which is good to know, right, and so understanding your baseline, like you said, steve, is super critical.

Speaker 3: 30:32

Yeah, yeah. So in terms of when we think about repair, cellular repair, the more and more popular approach now is intermittent fasting, fasting, mimicking diets, and I've heard people talk about well, you have to do, you have to fast for two days, 48 hours before that repair process takes place, and they know it's more or less on a continuum that you can. You can trigger the process after 1412, 1416 hours. What's your perspective on that?

Speaker 4: 31:11

Listen, the work done by Victor Longo at UCLA, I think is is pretty definitive and has been vetted by multiple studies. You know, the fasting mimicking diet actually just did it at this on January 2nd through 6th, right to start off the year, and it's a five day diet. The first day is 1200 calories. The second through fifth day is 800 calories and it's the prolon diet, is what it is and it I found it very easy to do. According to them, that diet is better than just a water diet, meaning the impact on under physiology and and knocking out your senile cells and get in stimulating autophagy is is higher than if you did nothing. So I found it sufficient enough that I'm. I'm going to probably do it once a quarter, at least twice a year, but I hope for once a quarter. The second thing I've just started doing in my abundance 360 community, steve, at the beginning of the year and we just did these back to back I'm going to do a 22 day, no sugar challenge and if there is one recommendation on diet over fasting, over intermittent fasting, over plants, over anything, it's eliminating sugar. You know, glycation of proteins, of cholesterol is a root cause for much cardiovascular and neurological disease and so I'm wearing my CGM, I've got my levels patch on my arm over here and let's see what my level is here right now. See, okay, I'm at 90, 90 milligrams per deciliter. And so I, you know, I look to make sure I have zero spikes during the day and trying to get my you know, my hemoglobin a one C is been at 5.3. I'm trying to get it down to five. We'll see if I can. If I can do that, I can grab a metformin near virtualize a friend, I believe the data that he has, and so, and then I'm also taking rapamycin. The data is reasonably good. Again, in animal studies. There is a rapamycin study that has just been initiated, I believe, to look at its impact, and right now it's a lot of trial and error for people. It's what do you feel is got enough upside and is safe enough for you and what makes you actually feel good.

Speaker 4: 33:57

I know that I feel better on a no sugar diet. It's difficult, for sure, but after a few weeks you can break the habit. It's, it is. It's addicting. Sugar is addicting. And again, going back to our hominid ancestors, 100,000 years ago, they didn't have sugar. It was no sugar cane plantations and you know M&Ms and snicker bars, I mean it. Just we never evolved for that.

Speaker 3: 34:30

And I know that I've heard you say sugar is poison. It is and, and you know it's one thing for people to know this, but it's it's also addictive. So in finding ways to eliminate it or reduce it, it's really a challenge to habitual behaviors of ours. So it takes us back to the, to the mindset issue, because really we have to be very incentivized and intentional in really following through with a lot of what would be good for us.

Speaker 4: 35:12

It is. It is you have to care enough about yourself and your physiology. And the mindset that I'm in is one that this I'm investing in my future and the future of my kids. I have two 11 year old boys and I'm excited about the future and I want to do everything I can to maximize my physiology and health to get there. And one other thing I'll mention. You know this 20 22 day, no sugar fast or no sugar diet. It's hard to do on your own, but we have a WhatsApp group with 140 of my of my 360 abundance 360 members, and every morning people are sharing their experiences, their weight loss, their energy levels, their tricks and trades and what they're eating, what they don't, and doing things in community settings is much better.

Speaker 3: 36:10

Yeah, I would totally agree with that. In fact, community and feeling a part of community is, I think, one of the keys to longevity as well, and it's been shown to be one of the key factors.

Speaker 4: 36:24

It is being loved and having a purpose and being in family and being close friends, all of things, things, very important.

Speaker 3: 36:31

Yeah, yeah. I noticed another startup of yours and you know I marvel at how many of these you're able number 26. Yeah, fantastic. The one I was thinking of is the vaccine. Oh yes, and you've talked about it as one of the goals there is a vaccine to address cardiovascular disease. Can you say a little bit?

Speaker 4: 36:57

about absolutely Absolutely. I'm super excited, yeah, super excited about it. So the vaccine is a company that manufactures a peptide vaccine against proteins in the body. So, unlike a vaccine that trains up your immune system to attack a foreign virus, this is looking at endo, you know, endogenous proteins in your body, and I have hypercholesteroemia my dad had it and I handle my, my high LDL levels by taking something called repatha, which is a monoclonal antibody, and it's monoclonal antibody against an enzyme in the liver called PCSK nine, and PCSK nine in the liver produces low density lipoproteins, which is the bad cholesterol, and so if you block the PCSK nine enzyme, you can reduce your LDL levels and it does it very effectively. And so in a vat, wherever they produce it let's say New York there's these clones of B cells producing these antibodies and the antibodies get delivered to me in a self injecting five ml syringe and I inject myself every two weeks in my thigh and it's great, but it's 1000 bucks in injection. It's, it's expensive. Right, I say five, I'm sorry, it's 1000 bucks a month, 500 bucks in injection and it's twice a week. So it's inconvenient at twice a month and expensive and I can afford it. But it's a third line defense, but if you can reduce your LDL levels, it is one of the greatest combatants against heart disease and stroke.

Speaker 4: 38:43

So a year or two ago we started an internal program to see can we develop a vaccine to stimulate your immune system to create the same antibodies produced by that vat of B cell clones? In other words, can you get your immune system to generate antibodies with high specificity against the PCSK nine enzyme? And in fact we can. We just finished our studies in primates and it was exceptional at or above anything else we've seen out there, and there is a very high conservation between primates and humans. So we're now entering human trials and unlike the $12,000 a year, this and injection you know, 24 injections a year this would be two injections a year every six months and cost 50 bucks.

Speaker 4: 39:48

So because these, these vaccines are very low in cost to produce and so what we have is the ability to do preemptive vaccination of individuals against developing heart disease and stroke. And there's evidence in lots of different societies that you know you can start to see cholesterol build up. Again. This is not just cholesterol by itself itself, it's all. It's glycated cholesterol, right sugar sticking to the cholesterol and sticking to the side and and generating soft cracks that can evolve and and cause a heart attack. So yeah, so this vaccine from vaccinity is super excited about it.

Speaker 3: 40:34

And again, what's the time?

Speaker 4: 40:36

frame. We're in human trials now I'm not sure we're in phase one for safety and we have this vaccine platform. We have had in hundreds, probably thousands, of humans for other targets this vaccine platform has been. We have a COVID-19 booster that has outperformed everything else that is looking for is in its registrational trial right now, but we also have a vaccine against Alzheimer's, against A beta. We have a vaccine against CGRP, for migraines, and one against Parkinson's too. So the system has been in humans and is safe and we just need to get the efficacious data to be able to go to registrational trial for that.

Speaker 3: 41:28

Do you engage AI in this development process?

Speaker 4: 41:32

We are just now. Honestly, any play of vaccine has got a very simple target list. Any place is a monoclonal antibody. We can train our system to produce those same antibodies that are manufactured outside the body as a monoclonal.

Speaker 3: 41:49

Well, this has been a fascinating conversation, peter. I so appreciate it, and we're in this field. That's almost like the wild west, where it's so rapid and so many things happening. So Rob and I are so very interested in not only finding what might work, but also what's safe, and it seems like that's also something that we should always take into consideration the safety of what we're doing.

Speaker 4: 42:20

Yeah, no for sure, I mean. I think what makes me the most excited is we have, in medicine, been flying for the most part blind since its inception, and it's just now really, with the emergence of sensors that we wear, that we inject, that we consume, that are in our environment, and then the massive power of AI, we're going to see a fundamental revolution, not in 10 years or five years, in the next two or three years, in which we're moving medicine out of the hospital, out of the doctor's office, into the home. I've got an Apple Watch. It's continuous glucose minor and aura ring, and there will be many others and all of my data will flow to an AI that knows what I ate for breakfast, lunch and dinner, how much I exercise, knows my genetics, understands my blood chemistries and, as a result of all of those things coming together, is able to reach conclusions, analyzing the data that no human ever could. And so this is the magic that's before us and what makes it exciting to be alive right now.

Speaker 3: 43:38

Yeah, definitely. Just the ability to measure and monitor increases a person's awareness, which in and of itself creates change. So all of this is wonderful. You have a great website. I've been on it, I've engaged in your mindset program and others. You have a wealth of information, thank you. How can people find that information? Can you give us the?

Speaker 4: 44:05

website. Yeah, if you go to just my last name, dmanduscom, I put out two tech blogs per week, typically on ones on health and biotech-focused ones on exponential technologies and how they're transforming industries there are. I'd have a program on finding your massive transformative purpose, and then on social media, I'm just at Peter Diamandus for Twitter and Instagram and I have a podcast called Moonshots and Mindsets, available wherever you get your podcasts, and it's really focused on what are the amazing moonshots that we're taking right now, and one of the biggest ones is adding 10, 20, 30 healthy years on your life. That bridges you to get the next 10, 20, 30 healthy years after that.

Speaker 3: 45:00

Well, we will look forward to all of us living that long and getting to that velocity stage where who knows what will happen next. So, Peter, again thank you very much. All of your links will be in our show notes so people will be able to reach you. So again, thank you so much.

Speaker 4: 45:19

My pleasure, steven, take care, you and Robert. Bye now.

Speaker 1: 45:24

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Speaker 2: 45:37

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Speaker 2: 45:42

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Speaker 1: 46:32

You wanna do it one more time. Okay, I think the other's good, yes.

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You need to say the recording Very good.