Health Longevity Secrets

How to Fast Without Fasting

• Robert Lufkin MD • Episode 228

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What if you could enjoy all the powerful health benefits of fasting without actually going hungry? Dr. Chris Rhodes, a biochemist with a PhD from UC Davis, has discovered a revolutionary approach that might make this possible.

During this fascinating conversation, Dr. Rhodes explains how fasting triggers a remarkable survival response in our cells. After about 24 hours without food, our bodies deplete glycogen stores and enter "true fasting metabolism," activating anti-inflammatory pathways, cellular cleanup mechanisms, and metabolic efficiency programs that can extend lifespan in virtually every organism studied.

The breakthrough came when Dr. Rhodes identified four specific metabolites that appear in human blood during a 36-hour fast. When combined and given to C. elegans worms, these compounds extended their lifespan by a staggering 96% - essentially doubling how long they lived.

This led to the creation of Mimio Health, a company developing supplements that recreate the molecular environment of fasting. Clinical studies show these supplements can maintain an anti-inflammatory state and cardioprotective benefits even while eating regular meals. Even more remarkably, eight weeks of supplementation reduced biological age by 2.5 years, increased free testosterone by 50%, and improved cholesterol profiles and glucose regulation. I am an advisor to Mimio Health, but I only work with companies that are based on solid science with a strong potential to help humanity.

Throughout our conversation, Dr. Rhodes offers thought-provoking insights about how modern eating patterns create chronic inflammation and how our bodies evolved with natural fasting cycles. He argues that constant eating without fasting windows may actually be the unnatural state for human metabolism - not the other way around.

Whether you're interested in longevity, metabolic health, or simply understanding how our bodies respond to food, this episode offers a compelling look at cutting-edge nutritional biochemistry that could change how we approach health optimization. Ready to discover how your body might already possess the blueprint for extraordinary health and longevity? Listen now and learn how to activate it.

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Speaker 1:

Welcome back to the event. Our guest will be speaking on the interesting question of is it possible to trick our body into thinking we're fasting? You're going to learn what supplements we can provide the body that will provide the benefits of fasting when you stay through the end of the event. Our presenter for this discussion is Dr Chris Rhodes. He received his PhD in nutritional biochemistry from UC Davis. He's an expert on human fasting as a health and longevity intervention. Dr Rhodes has discovered the body produces multiple unique bioactive metabolites that we're going to be hearing about. He is now the founder and CEO of Mimeo Health, a nutrient technology company that is creating first-of-their-kind biomagnetic supplements designed from human biology to recreate our body's natural regenerative systems.

Speaker 1:

So let's go ahead and jump on in. Hey, chris, welcome. Hey, rob, how's it going? Thanks for having me. Hey, great, today. It's going to be so interesting. We're going to explore the question is it possible to get the benefits of fasting without actually going through it? And this is going to be a great conversation, I know, but before we get into details, maybe you could just take a moment and talk about fasting a little bit. And what is fasting? First of all, let's define that.

Speaker 2:

Yeah, it is actually like a very oddly controversial question, but you know, just by and large, fasting is the abstinence of food and caloric intake, right. So going for extended periods of time without actually taking in any calories, that is essentially fasting. How long that, you know, prolonged time period is, that's more of the thing that's up for debate. You have a lot of studies that look at the most popular, which is that 16-8 style, where you have a 16-hour fasting window with an eight-hour eating window. You have one meal a day. That's, you know, basically 24 hours of fasting. You have alternate day fasting, that's around 36 hours of fasting, all the way up to 72, multi-day fast, like week-long fasts, and all of them kind of have their own distinct benefits and kind of things that happen along that fasting pathway that change within the body that can give you, you know, different benefits or, you know, at certain points, like different drawbacks.

Speaker 1:

So so yeah, fasting can mean a lot of different things to different people, and and even people fast before surgery just to not have food in their stomach, which is a different reason. But we're talking about fasting for health and longevity benefits, just to be clear. So you mentioned that at different times along the fasting window there are different benefits that tend to accrue or different things that happen. Maybe you could expand on that a little bit.

Speaker 2:

Yeah, absolutely so. The timeline of fasting is really interesting, especially from a biological perspective. You have a lot of distinct things that happen during fasting that are a little bit different than something like caloric restriction, where you are taking in some calories in fasting because you're not taking in any calories. That's really switching your metabolism over to relying on endogenous energy sources, and the first place that your body goes to to start harvesting that energy is usually your glycogen stores. Your glycogen is your stored carbohydrates sits around in your muscle, but primarily in your liver as well, and when your body starts running through that, it's breaking down glycogen for glucose, which is, you know, your brain's preferred fuel, your body's preferred fuel. But once that is gone and depleted, that's where you really start getting into true blue fasting metabolism. And that doesn't really happen until around 20 to 24 hours of fasting and that's where you really start to just begin to enter into fasting metabolism. You have this metabolic switch that happens going from glucose and carbohydrate metabolism into ketone and fat metabolism. So your body starts breaking down fat and a little bit of muscle as well at that point in order to fuel the body and especially the brain, which can rely on either glucose or ketone bodies. So that's really where fasting metabolism begins and that's kind of where you start seeing, like I said, that big metabolic switch switch.

Speaker 2:

And that's where you'll really start to get into what we canonically think of as the benefits of fasting. So these anti-inflammatory effects that happen, the initiation of autophagy or cellular cleanup and recycling mechanisms, a lot of the cardioprotective effects, you know, the cellular renewal that happens, a lot of changes in the DNA structures, the epigenetics, changes in the DNA structures, the epigenetics all of that is really initiated at around 24 hours of fasting and kind of progresses through to around 72 hours of fasting where you kind of reach more or less this steady state. And that's one of the longest periods of time that we've really looked at in terms of getting fasting benefits. And that's where we've seen before kind of this immune cell regeneration and this reset of the immune system that can be very beneficial for folks with autoimmune diseases. But that's kind of, you know, the longest we've really seen so far about what kind of benefits you can get from fasting.

Speaker 1:

So that 72 hours would be three days then I guess yeah, three days, much longer than most people will ever really experience.

Speaker 1:

So now some people, some of our audience even may be on what's called a ketogenic diet, and that's where they restrict the number of carbohydrates but still keep protein, still keep protein levels up and maybe even increase their fat in their, in their diet, but in doing so they, they, they may lower their glycogen stores and they may also be in ketosis. So they're at least one metabolic switch is switching to burning ketones instead of the other one. So how is that different from fasting, or is that the same thing?

Speaker 2:

Yeah, they're similar in the sense that you are producing ketones in both of those situations, in both of those, uh, both of those situations. Okay, we're good, all right, yeah, so I can, I can start from the beginning there, so, uh, that's good.

Speaker 2:

Keep. Yeah, yeah, that's good. Yeah, so they're. They're similar in that you know they're both producing ketones, right, um, but the main difference is that fasting is a much more complete and holistic metabolic shift than necessarily ketogenic diet, because you have energy restriction, that's on top of the actual production of ketones coming in, so the system doesn't actually go into. You know the benefits that you would get during fasting or caloric restriction, because you're not actually reducing cellular energy. You're just changing the source of the energy from, you know, the glucose to then the fats that become ketones. So it's shifting metabolism around while still providing enough energy to maintain the organism versus chloroprotection and fasting. That has its own distinct effects because you have the energy restriction on top of that, which triggers a lot of these. You know cellular survival mechanisms. So one of the most interesting things about fasting and one of the reasons why I got really interested in it and one of the reasons why I got really interested in it is that fasting is one of the most reliable ways that we know of to actually extend lifespan in model organisms and it has this really interesting effect on cellular functionality and kind of activates this cellular survival mode.

Speaker 2:

So when you think about it. From an evolutionary perspective it makes a lot of sense. You have, you know, in a nutritionally optimal state, right, you have all the energy you need, you have all the proteins and nutrients to be able to, you know, make all the proteins you want, make all the cells you want. That's giving a signal to your cells, essentially, that they can run dirty. You know. They don't have to really be worried about not having enough energy, not having enough nutrients, you know, not taking on a lot of damage. If something goes wrong, it's fine, I can just make a new cell, right, I can make some new proteins, I can just fix anything that's happening. And it's not that big of a deal.

Speaker 2:

In the context of fasting, that kind of gets flipped on its head.

Speaker 2:

So all of a sudden there's no nutrients around and your cells get this signal that like, oh crap, you know, if something goes wrong, if a cell gets damaged, then I don't have the energy, I don't have the building blocks to be able to build another cell or make another cell.

Speaker 2:

So I have to spend a lot of time and attention making sure that this cell is safe, secure, healthy and protected, because I'm not going to be able to get a second chance with a new cell. So that turns on things like autophagy for cellular recycling and regeneration, like breaking down dysfunctional organelles and proteins and creating new functional ones, really enhancing metabolic efficiency, reducing mitochondrial waste, reducing inflammation in the cells, because that's kind of like you know their big, their big, oh shit meter. Pardon my language, but inflammation is kind of, you know, like a state of alert and your cells kind of need to dial that back to a certain degree. So fasting kind of initiates this big systemic shift in cellular function that actually promotes maintenance and protection of the cell for as long as possible, which ultimately translates into longevity, right. So that's kind of how fasting and a ketogenic diet are. Different is because that energy restriction component really keeps the cells on their toes and keeps them like functional and protective of themselves, rather than just, you know, using utilizing all the nutrients that are around them.

Speaker 1:

Yeah, it's interesting. I mean, fasting seems like something that's abnormal. You know that, maybe certainly religious traditions, almost every religious tradition has a fasting component to it but it's something that humans wouldn't normally do. Believe that fasting is actually the normal obviously we can't fast forever sort of. I guess periods of fasting where we fast for a while and then we eat, then we fast for a while and eat, is actually the normal human metabolic state, over which humans evolved for tens of thousands of years, prior to the advent of agriculture, about 12,000 years ago, which meant that food was widely available and people didn't wind up fasting anymore, even for a week at a time in many cases, unless it was intentional or for religious reasons like that. Do you, how do you feel about about fasting as far as its role in human, human history and and relative to human beings?

Speaker 2:

Yeah.

Speaker 2:

I think, that we have definitely, over an evolutionary period of time, been kind of designed to fast, right, it really wouldn't make all that much sense if we, if we, needed to eat three meals a day right from the inception of the of the human race. I think that we'd all kind of be dead right now. So yeah, like having having that evolutionary context of fasting is really important because it kind of helps us realize that we're in a very weird state nutritionally in modern society, right, like it was very much the case that we used to have to go out, hunt our own food, put in the exercise, roam around to either like hunt something, kill it, cook it, eat it, or, you know, graze and gather like berries or nuts or whatever else that we could actually find. And you know that wasn't always. It wasn't like going to the grocery store, right. That wasn't always going to be available. So there were going to be periods of, you know, feast and famine. That just naturally happened.

Speaker 2:

And I think the really interesting thing about fasting is that we as a modern society very much associate fasting, or, you know, starvation, with poverty and times of big economic stress and it's almost kind of like a socially unacceptable thing, right, whereas in reality it's the constant eating that's kind of messing with our health over time, because you get into the situation of chronic inflammation that comes along with constant eating. Because every time you eat you're taking a foreign substance and you're putting it in your body, right, number one that's going to trigger an immune response and that's varies in degree from, you know, if you're eating broccoli versus if you're eating a, you know, bacon, double Western cheeseburger, right, but still all of it is a foreign molecule that's coming into your body. Your immune system is going to react to it, regardless of what it is. So there's always a certain degree of post perennial inflammation that happens. And so when you get into this system of, you know, three meals a day plus snacks, the resolution of that post-prandial response takes around four to six hours.

Speaker 2:

So when we are like eating that three meals a day plus snacks kind of situation, you know you would have a typical curve where you're eating, there's the post-prandial response and then it, you know, dissipates over that four to six hours. But when you eat every three hours you're kind of just continuing to stack those curves on top of each other. So you're almost in this state of constant, chronic dietary inflammation that then goes on to create this, this system of damage that can be really harmful over time, because inflammation is one of those underpinnings of almost all disease and disease progression. So fasting can really be helpful for taking that break, providing a reset to your system and allowing yourself to actually, you know, come down from the stress of eating.

Speaker 1:

Yeah, now you've um. You've mentioned that um mechanisms occur over time as the fasting increases the length of fasting. What's the evidence for the frequency of fasting? In other words, should we do it once a week, once a month, once a year? Uh and and I know it's hard to get at that kind of data, but what? What evidence is there out there?

Speaker 2:

Yeah, what we see in the literature is that, you know, there's a lot of different gradations of fasting, like we were talking about before, and each one of them has, you know, a certain amount that it was actually studied, certain amounts of data that it has behind it and certain amounts of you know actual like markers and indications that it's been shown to be helpful with. So when we're thinking about what you know the right level of fasting is, it really depends on what job you're trying to do, right? So in the case of, like what I'm really interested in, longevity, we've seen that alternate day fasting has kind of been the best for promoting healthspan, promoting longevity in model organisms, and that's, you know, one of the things that we've seen in the limited human trials that have been done has also been very helpful for, you know, bringing back a lot of potentially harmful like risk markers for cardiovascular disease, for neurodegenerative diseases, for autoimmune diseases, because that's where, like we were talking about, you kind of get this systemic switch into true blue fasting metabolism, that initiation of autophagy, that initiation of that cellular you know survival mode, that bio program of longevity. So that's really where I focused my research, that's where I like to look at things. But then you have, you know, like 72 hours of fasting right, which has been shown to be really beneficial for that, you know, immune cell reset that you don't really get in the earlier stages of fasting. Then you have the 16, eight style of fasting. That's really been more assessed for its, for its weight loss ability and for some measures of cardiovascular health and metabolic health specifically. And that is, I think, where you see a lot of wishy-washy data when it comes to fasting, because 16-8, you know, is a typical.

Speaker 2:

You know people typically experience a 12-hour overnight fast, right. If you have your last meal at 8 pm, you don't eat again until 8 am. That's 12 hours of fasting, and so adding an additional four hours on top of that isn't really going to do much in terms of, you know, switching around your holistic metabolic function right. 16 eight is unfortunately kind of like glorified skipping breakfast, and that's really what you see in the literature as well. That's where you're going to get the least robust effects of fasting and that's going to be the most similar to caloric restriction. So when we're talking about, you know what's the what's the right fasting for the job, I tend to tell people that you know the 24 hour OMAD style is at least where you should start. That's where you'll at least get to the depletion of the glycogen stores and, like, really start entering into fasting metabolism. But the alternate day fasting is kind of you know where you'll, where you'll see the best healthspan results.

Speaker 1:

Well, now let's talk about your work. It's fascinating. How did you get into that, and what sort of things did you uncover?

Speaker 2:

Yeah, yeah, absolutely. So I got really interested in fasting after I got out of college. So I got my BS in biochemistry from Loyola Marymount University down in LA, got out, but then, like a lot of college kids, didn't really know what I wanted to do. I knew I wanted to be something in research, but just wasn't, didn't have anything that quite like lit me up inside as a passion yet. So I took an immunology fellowship at Stanford where I just started pouring through all the research I could get my hands on, going to all of the seminars that I could go to, eventually came across longevity and healthy aging research, which I thought was fascinating because it's one of those things that used to be, you know, very mythological, legendary Ponce de Leon and all that fountain of youth stuff, but is now this incredibly active and incredibly robust area of scientific study. And when you're in that space, of course, you eventually come across fasting because, like we said, it's one of the only ways that we know of to reliably extend lifespan. And I thought the most amazing part about that was that fasting can help to extend lifespan, help to prevent, treat or delay most major diseases, but then does all of that without actually adding anything into the system, right? So it's not this superfood or this wonder drug, but it's somehow activating that cellular survival mode, this longevity bio program that we all already have inside of us but just isn't ordinarily activated. And when that clicked for me, I got mad about it Because it was just like okay, so my body knows how to be, you know, in perfect health and live to 120 years old, but it's just not doing it. So that was my big, like fiery passion moment of like all right, I need to like figure out how to like kick my biology into high gear, like what is happening in the human body and during a fast. That could be, you know, initiating this longevity bio program. And is there a way that we can recreate it and activate it on demand so we can get those benefits of fasting but without actually having to fast?

Speaker 2:

And that's what I spent my PhD work doing at UC Davis, got my PhD in nutritional biochemistry, and what we did there was essentially have 20 people come in and fast for 36 hours. So everybody was very happy with me and that study. But, like I said, 36 hours is kind of what you would experience in a typical alternate day fast. And we looked at their before and after and the first thing that we saw was that when people fast for 36 hours, they had this big bump in plasma functionality. So they became much more optimally functional, much more, much more healthy overall. They became more anti inflammatory, they became more antioxidant, cellular protective, became more cardio protective, had better metabolic indications. So that was really significant for us, because taking already young, healthy people and doing a single 36 hour fast and essentially turning them into, you know, super people was really really fascinating. You don't get those kinds of results in the nutrition space.

Speaker 2:

So we wanted to really understand what was happening between the baseline state and the fasting state that could be causing these differences.

Speaker 2:

So we did what's called comprehensive metabolomics, basically looking at all of the small molecule components of the plasma, and what we found was that there were over 300 significant differences between a baseline state and the fasting state.

Speaker 2:

And when we screened through that list of 300, we were able to identify this synergistic combination of four of these metabolites that when we combine them together combination of four of these metabolites that when we combine them together could recreate the beneficial cellular effects that we had seen in the plasma.

Speaker 2:

So just by taking these four, you know, fasting metabolites and applying them directly to human cells, we could recreate these cellular health benefits of fasting, those same anti inflammatory, antioxidant, cardioprotective you know metabolic balancing effects, just through the bioactive metabolites. And of course, because this was also a longevity study, we also wanted to see what the impact of these metabolites on lifespan would be. So we did a C elegans lifespan analysis and found that supplementation with these fasting metabolites was able to extend lifespan in C elegans by 96%, so basically doubling their lifespan. Just through supplementation, so essentially by, you know, recreating the molecular environment of fasting, using these bioactive metabolites, taking what the body already makes during a fast and then, just, you know, giving it back to the cells, you can initiate these same cellular pathways and processes and mimic the benefits and the effects of fasting, but without actually having to do the fasting.

Speaker 1:

So let me see, if I understand this, then the the human, human volunteers. So this is important, it's a.

Speaker 1:

It's a human study we did this. It's not mice, it's not a yeast, but it's humans. So in this human study, you had them fast for 36 hours, then you took their plasma and you found certain, certain metabolites that were present after the fast, that were not present before the fast. You isolated them and then you gave them and they were associated with beneficial effects and then, when tested in C elegans, they had this amazing lifespan extension. What were those metabolites and were they what you, you expected, and how did it work?

Speaker 2:

So some of them are a little bit what we were, what we would expect. So two, two of the four metabolites nicotinamide number one so like the big NAD precursor in the body, that was, like, very expected. That's kind of the one of the major ways that cells sense their energy environment, so if you have a higher NAD plus to NADH ratio, that's essentially a cellular signal that you don't have a lot of energy, and that kind of starts kicking off all of those cellular survival mechanisms that we were talking about before, so definitely expected to see that. One Another was spermidine. Spermidine is really highly associated with autophagy, so not surprised to really see that one at all, especially at the 36 hour of fasting mark, really kicking off those autophagic processes, that cellular recycling and metabolic efficiency pathways.

Speaker 2:

Ones that we didn't really expect to see, though, and the two that kind of ended up becoming my favorites were palmitoyl ethanolamide PEA and oleoil ethanolamide OEA, and both of those two things are lipid amide derivatives of palmitic acid and oleic acid, and the reason why we didn't expect to see them was because they've never been associated with fasting before and, really interestingly, oea is usually associated with eating a meal. So typically, eating a meal increases the production of OEA because it's a satiety factor and a PPAR alpha agonist, so like, really associated with lipid metabolism. So it makes sense that it would be upregulated in fasting, because you have a lot of, you know, lipid metabolism. That's happening especially as you deplete your glycogen stores. But we were the first to really show that like, yes, it is increased in a postprandial state, but it's really increased in a 36 hour fast.

Speaker 2:

And I think that that's really fascinating because it's kind of like your body's adaptation mechanism to fasting is, as you get into those later stages of fasting, people do typically find that the hunger that they experience in the early stages tends to just, you know, kind of go away and not be as present anymore, tends to just, you know, kind of go away and not be as present anymore.

Speaker 2:

And I think that one of the main reasons for that is that the body starts overproducing OEA as a satiety factor to help kind of like keep you focused on, you know, finding food and survival rather than constantly being, you know, bogged down in hunger. And then palmitoylethanolamide PEA is another really interesting one because it's kind of like your body's natural CBD. It's an endocannabinoid. It's involved in going to the brain and stimulating the release of anandamide, which is like a bliss molecule essentially, but also has these very potent anti-inflammatory properties as well as pain relief qualities as well. Lots of clinical studies showing that PEA has a pretty significant effect on pain relief. So really helping to, you know, keep your body in a non-inflamed state, like we were talking about before, but then also helping to, you know, enhance mental clarity, enhance mood and decrease pain so that you can again, like, go out, find the food, get the job done, but without being bogged down by this, you know, big, this big depletion of energy and fatigue.

Speaker 1:

Yeah, it's fascinating, those molecules they're. They're some of them. Are you know, like would be expected the NAD and the spermidine, but the others are less expected. How does that fit in with? You know, a lot of people do drugs like metformin, rapamycin, for mTOR or AMP kinase. Do you see it fitting in with those, or is that? I mean is is are we talking about the mTOR switch from from satiety and autophagy? I mean rather energy, nutrient presence versus nutrient absence and autophagy versus growth. Is that the switch? Or I mean I guess there are many switches in our bodies. That's the thing.

Speaker 2:

There are definitely many switches so there hasn't been a ton of evidence for these molecules in actually altering mTOR signaling specifically. But yes, amp kinase both OEA and PEA are big AMP kinase activators. If you get enough nicotinamide in there, that's also going to be an AMP kinase activator, specifically through that whole NAD cert. You know, pathway association.

Speaker 2:

Spermidine is interesting because people don't like we're still trying to figure out how exactly is spermidine enhances autophagy, because right now it's basically like spermidine inhibits, an inhibitor of autophagy, but it's not specifically through like the um, so it's depression of mTOR signaling. So we are talking about a lot of, you know, the um, the positive activator pathways of fasting the AMP kinase, the PPAR alpha, the NAD cert pathways, um, nrf, uh activation, erk activation, things like that. These are kind of those like bioactive signalers that help activate those pathways. What we don't see of is more of like the growth depletion elements of it, like you know, decreasing IGF-1 or decreasing mTOR, because that's not really the point of the molecules. Those pathways would more or less be down-regulated due to the energy restriction, whereas these are more of the like. Okay, let's turn on the fasting pathways.

Speaker 1:

Yeah, and you've taken these compounds based on this work and founded a company to make these available for human use, really as a biomimetic supplement. That mimics fasting. I guess with fasting, like we've talked about, we don't do it all the time because it's a hypercaloric state, it's a catabolic state. With these molecules, is it necessary to cycle them? Do you think sort of like fasting or do you recommend a continuous application? What is the evidence there?

Speaker 2:

Yeah, that's a great question. So, yeah, to give you more background on the products yes, so we do make a product we're Mimeo, mimeo Health, and it is the biomedic fasting memetic supplement and that is taking those four molecules nicotinamide, spermidine, pea and OEA, combining them together in their most bioavailable forms and giving them back to people as a supplement. And we did run an initial clinical study to make sure that. You know, we saw that this worked in human cells and in C elegans, but also wanted to make sure that it actually worked in humans as well. So what we did for that study was we had people come in, eat a standardized breakfast alongside a placebo control and then assess their plasma functionalities, as we had before.

Speaker 2:

And or had those same people come back after a washout period, eat that same standardized breakfast, but then with supplementation with Mimeo, and what we found was that when people had the standardized breakfast alongside the placebo, they had this big loss in plasma functionality which is really typical of the post-prandial state. Right, you have all that foreign material kicking off immune responses. You have all the nutrients coming in, kind of throwing the system out of homeostasis into more metabolic chaos. Right, what we saw was that their plasma became pro-inflammatory, less antioxidant, cellular protective, less cardioprotective, as measured by cholesterol efflux capacity, and then of course, their metabolic markers were kind of all over the place as well insulin and glucose levels, all that fun stuff.

Speaker 2:

What we saw with that same standardized breakfast, but then with supplementation with Mimeo, was that we could prevent all of that loss of function and then actually add gains of function on top of that. That mimicked what we saw when people were actually fasting. So instead of being pro inflammatory, their plasma became anti-inflammatory and antioxidant and cardio protective, had a like very increased cholesterol efflux capacity, and that was kind of our indication that you know, using these fasting metabolites, this fasting memetic formulation, at the same time as eating, you know, we can basically stimulate a lot of these beneficial like counterbalancing fasting pathways at the same same time as the food is coming in and really help to kind of steer the system more towards that beneficial, regenerative fasting state by activating those beneficial pathways even during a meal.

Speaker 1:

So, so, okay, so we, we do a continual daily dose then, yeah, so, yeah, what?

Speaker 2:

what we, what we recommend to people, is a continual daily dose then yeah, so yeah, what we recommend to people is a continual daily dose and we usually recommend that people take it alongside their first meal, kind of as a natural way to, you know, keep themselves protected from these you know damaging post-prandial effects. But then also to kind of help take advantage of some of the other benefits of the product, like that increase in satiety, like the mood elevation, the pain relief elements, the reduction in postprandial inflammation. But then we also see from the C elegans data that you know, continuous supplementation with Mimeo over a lifetime. We is where we got that great 96% lifespan extension. So we haven't really experimented all that much with cycling. I think that there's always a, there's always a place for cycling in any, you know, supplementation regimen. But we have seen that consistent use is not detrimental but it's actually incredibly beneficial. So that's more or less how we tell people to take the product.

Speaker 1:

And if I'm, let's say, I'm already taking an NAD supplement, NMN or NR then with Mimeo I wouldn't need to do that as much. Right, because there is that would be provided by the Mimeo.

Speaker 2:

Yeah, that's right, so yeah with the nicotinamide that's in the Mimeo product. We're giving that at a dose of 500 milligrams per day, which is, you know, more than you would experience on your typical NMN or NR dosing schedule. And the great thing about nicotinamide is that it's the upstream precursor to NR and NMN and 1-methyl nicotinamide and NAD and all of those other molecules. So you're really getting more of a broad spectrum effect than using any one of the specific ones. And you're still getting all the benefits of increased NAD production, and that's been shown out, you know, in clinical studies going as far back as the 80s, right? So you kind of get more bang for your buck using nicotinamide versus something like NMN or NR and any contraindications.

Speaker 1:

Any people shouldn't take this.

Speaker 2:

Yeah, we definitely say that folks that are nursing or pregnant probably shouldn't be on Mimeo. And that's not because the molecules themselves aren't safe. Right, they're all natural human metabolites that the body normally produces. But we just don't want to take any risks for you know that developmental state in life. But otherwise we do know that some folks do have a genetic sensitivity to nicotinamide or niacin and they could have some GI troubles or like bloating that happens from taking high doses of nicotinamide. But that would also be the case for, like NMN or NR. But those are kind of the two, the two populations where we would say just to give it a break, back off of it. Or in the case of the niacin sensitivity we found, a lot of folks can take the product but they have to take it with food or else they'll get some of those negative GI or headache kind of effects.

Speaker 1:

And any tests to follow. Does it affect any lab tests that we? Can look at.

Speaker 2:

Actually, yeah. So we've been doing some case studies in a partnership that we have with Mount Sinai out of New York and we've gotten some really great data back from there that eight weeks of supplementation with Mimeo can actually affect a lot of different health markers. So very exciting for us is that we were able to decrease biological age by two and a half years after just eight weeks of supplementation and that's one of the first times that we've actually seen a supplement on an interventional basis actually be able to reduce biological age. So that's a big, a big win for us. So you can track it we were just using the true me diagnostic tests so people can do a before and after with their Mimeo supplementation and track through biological age.

Speaker 2:

We were also able to, very interestingly, increase free cholesterol by about 50%. Increase free cholesterol by about 50%, which was or sorry, free testosterone by about by around 50%, which is pretty amazing. It speaks to kind of like the potential, you know, rejuvenating fertility aspects of the product. We were also able to reduce total cholesterol while reducing LDL cholesterol and increasing HDL cholesterol and triglycerides, which was also very exciting. We were also able to reduce HbA1c levels. We were also able to reduce glucose and insulin levels. So all very, very promising and really speaks to the holistic, metabolic and potentially longevity promoting aspects of the product potentially, you know, longevity promoting aspects of the product.

Speaker 1:

Now, this is so exciting, chris. How can people maybe you could tell them how they can find the website and also how can they follow you on social media and keep up with what you're doing here?

Speaker 2:

Sure, absolutely so. If you want to learn more about the products, actually look at our clinical studies, see the science behind us you can go to MimeoHealthcom. That's M-I-M-I-O-Healthcom. More of that on my TikTok channel. I'm, at that, nutrition doctor with a DR, not an actual doctor. I've got around 150,000 followers there, so you'll be in good company and you can hear me scream about nutrition into my bathroom mirror, because what else is TikTok for?

Speaker 1:

That's great. Well, this this has been fascinating today. It's so interesting. Chris, thanks for spending time with us to help us understand fasting and the unique work you're doing with these biomimetic molecules, and also thanks so much for all the great work you're doing.

Speaker 2:

Yeah, absolutely. Thanks so much for having me, Rob. This is such a good time.

Speaker 1:

I want to thank Chris Rose for joining us today and sharing his amazing knowledge with us all. Remember that Chris is giving a bonus to our listeners, especially our VIP Pass members. If you still haven't claimed your VIP Pass to access the recordings, the transcripts, the MP3s and, of course, our must-have bonus package, you can get it now by clicking the button on this page to upgrade before it's too late. Remember that when the event is over, the recordings and all the bonuses go away, so make sure you claim your VIP pass before it's too late.