Out of Pocket

Why Alcohol Hits Harder As You Get Older | Ep 71

Andrew Hayes Season 1 Episode 71

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0:00 | 24:36

One or two drinks and your sleep is wrecked. You’re up at 3am anxious. Your face flushes. Your stomach is bloated. The hangover lasts all day.

Five or ten years ago, you were fine.

In this episode, Kat and Andrew explain why alcohol tolerance is actually a health signal, not just a sign of “getting older.” As stress accumulates, hormones shift, gut health changes, and liver detox pathways get overloaded, your ability to process alcohol changes with it.

They break down how alcohol competes with estrogen for detox pathways, why cortisol and blood sugar instability make hangovers worse, how gut permeability and histamine responses amplify bloating and flushing, and why metabolic health plays a major role in how your body handles drinking.

(01:10) Why alcohol tolerance changes over time
(06:00) Liver detox, estrogen, and cortisol competition
(12:30) Gut health, histamine, and bloating
(17:45) Metabolic health, fatty liver, and what to test

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