Frozen Shoulder: A Systemic Immunometabolic Disorder

PHYSIO MOSMAN: https://www.fitasaphysio.com/

This academic review re-examines Frozen Shoulder (FS), traditionally seen as a localized orthopedic problem, by proposing an integrative systemic model linking the disorder to immunometabolic and endocrine dysfunctions. The central focus is on estrogen deficiency and resistance, noting the disproportionate effect of FS on perimenopausal and postmenopausal women. The article explores how factors such as thyroid dysfunction, endothelial damage, metabolic stress (high HbA1c, dyslipidemia, AGEs), and adverse lifestyle factors (poor sleep, stress, EDCs) converge to create a state of chronic low-grade inflammation and a profibrotic environment in the joint capsule. This new paradigm advocates for integrative, personalised treatments that target systemic hormonal and metabolic imbalances alongside traditional physiotherapy.

READ MORE: https://www.fitasaphysio.com/blog/5-surprising-truths-about-frozen-shoulder-that-go-beyond-the-joint