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Serenity and Fire with Krista
Welcome to Serenity and Fire. The podcast where wellness meets grit. I'm your host, Krista Guagenti, founder of Panacea Luxury Spa Boutique. Join me as we dive into the intriguing world of bio-hacking, clean living, cutting-edge spa treatments and the hustle, grind and grit of entrepreneurship. From my personal battles with weight-loss and infertility, to a 30-year struggle to create and launch my dream business, to building a sanctuary for those touched by cancer — I'm here to share real talk, inspire big dreams and spark a passion for holistic living inside each and every one of you.
Episodes
72 episodes
100 Miles of Hope: Breast Cancer Awareness and CancerFree KIDS
One in eight women in the U.S. will be diagnosed with breast cancer in her lifetime. This Breast Cancer Awareness Month, Krista Guagenti, founder of Panacea Luxury Spa Boutique, Ohio’s first oncology-focused spa, shares what the 2026 breast can...
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Peptides Unpacked Ep 11: Where I Stand on Peptides Now
When this series started in June, BPC-157, TB-500, KPV and Semax had no lawful compounding pathway in the United States. In July, an FDA advisory committee voted to recommend all four, plus two more, over the objections of the FDA's own scienti...
Peptides Unpacked Ep 10: Do Skincare Peptides Actually Work?
Are the peptides in your skincare serum actually doing anything — or are you paying for marketing? In this episode, we break down what skincare peptides really are, which ones have real evidence behind them, and how to tell the difference just ...
Peptides Unpacked Ep 09: The Dihexa and Semax Conversation
“Brain healing” is one of those phrases that can make smart people stop asking questions. We don’t. Today we put two compounds under a bright light and let the evidence, the mechanisms, and the missing pieces speak for themselves: Dihexa and Ce...
The Things Women Whisper: The Conversations We're Not Having Out Loud
What happens when six women sit around a table—with no script, no rehearsed answers, and permission to talk about the things women are really thinking?In this special roundtable episode of Serenity & Fire, we pulled up six chairs in...
Peptides Unpacked Ep 08: Semax, C-Link and the Future of Brain Health
People talk about “brain peptides” like they’re interchangeable shortcuts to focus, memory, and neuroprotection. They’re not. Today I put two of the most commonly paired compounds, CMAX and C-Link, through the same Serenity and Fire checklist s...
Peptides Unpacked Ep 07: Can Your Brain Heal Itself? The Science Behind Brain-Healing Peptides.
“What if the brain could heal itself?” sounds inspiring, but it’s also a massive claim. We slow the hype down and get specific about what “brain repair” would actually require at the cellular and network level, before we ever debate a single pe...
Peptides Unpacked Ep 06: The Functions, Benefits, and Science Behind Growth Hormone Peptides
Growth hormone peptides get marketed like a magic lever for muscle, fat loss, sleep, and longevity, but the real story is messier and far more interesting. I walk you through the five most discussed “growth hormone optimization” therapies and e...
Shelf Worthy: Honest Skincare Hacks and the Products We Love
You can spend a fortune on skincare and still feel stuck, or you can get ruthless about what actually moves the needle. We sit down with Cayley for a final round of skincare truth telling, starting with our favorite “easy wins” that people don’...
The Glow Guide: The Tools That Actually Transform Your Skin
Your routine doesn’t need to be complicated, but it does need to make sense. Krista Guagenti sits down with Cayley Rich, our esthetician and aesthetics manager at Panacea Luxury Spa Boutique, to map out a clear, repeatable skincare routine you ...
Skincare Made Simple: Why Some Skincare Works and Some Doesn't
Skincare gets loud fast: 12-step routines, miracle acids, “clean” labels that mean nothing, and advice that changes depending on who you ask. Krista Quagenti sits down with Panacea Luxury Spa Boutique aesthetics manager and sales training manag...
Peptides Unpacked Ep 05: The Real Impact of Growth Hormone Peptides
Fifteen to twenty years ago, human growth hormone was marketed like a miracle: lose fat, build muscle, recover faster, slow aging. Some people spent thousands and felt a real change, while others got almost nothing. That gap isn’t a mystery onc...
Peptides Unpacked Ep 04: The Truth About BPC-157, TB-500 & KPV
Peptides seem to be everywhere right now. Depending on who you ask, they're either the future of regenerative medicine or just another wellness trend.The truth? It's more nuanced than that.In this episode of Serenity & Fir...
Peptides Unpacked Ep 03: What If Better Healing Starts With Better Questions?
Peptides are suddenly everywhere and if you’ve ever googled BPC-157 or TB-500 after a stubborn injury, you already know how fast the advice turns into chaos. One link promises “miracle healing,” another warns you to stay away, and even doctors ...
Peptides Unpacked Ep 02: A Real Conversation on GLP-1s
GLP-1 medications are everywhere, and for people who have fought their weight for decades, the results can feel like someone finally turned down the volume on cravings and “food noise.” I’m Krista Guidenti, and I’m equal parts fascinated and ca...
Peptides Unpacked Ep 01: What Peptides Are Actually Doing in Your Body
If you've ever heard the word "peptides" and thought… "Is that just another wellness buzzword?" — this episode is for you.In this week's Serenity and Fire episode, I'm breaking down what peptides actually are, why they're showing up everywh...
Hormone Therapy & Cancer Risk: The WHI, Breast Cancer, Testosterone & What We Have Learned
Do hormones cause cancer? What did the Women's Health Initiative (WHI) actually show? Does hormone replacement therapy increase breast cancer risk? And what about testosterone therapy in men?In this episode of Serenity & Fire
Hormone Replacement Therapy: Bioidentical Vs Synthetic — Does It Really Matter?
If you're considering hormone replacement therapy (HRT), you've probably heard conflicting advice about bioidentical hormones versus synthetic hormones. Are bioidentical hormones safer? Do synthetic hormones still work? Does the di...
Why You Feel Off: The Hidden Hormone Connection That Has You Not Feeling Like Yourself Anymore.
Do you feel exhausted, overwhelmed, anxious, unmotivated, or like you've simply lost the version of yourself you used to know?You're not alone.Many people assume fatigue, weight gain, mood swings, brain fog, poor sleep, low libido...
Creatine: The Brain and Body Booster
Creatine has a branding problem. And it's time we talk about it.Despite being one of the most researched supplements out there, creatine is still largely seen as a "gym bro" thing — and most women have never been told it might actually b...
The Missing Biohack: Why Your Nervous System Can't Recover.
You can do everything “right” and still feel completely exhausted.The supplements. The workouts. The clean eating. The sleep tracking.And yet… you still wake up tired, overstimulated, and running on fumes.In this episode, we...
The Good, Bad, and Ugly of Building Something You Love w/ My Friend, Keri Croft.
Sometimes letting go of something is the most strategic thing you can do.In this episode, Krista opens up about the decision to close her lash and brow studio — what looked good on paper, what changed behind the scenes, and the emotional...
Letting Go to Grow: Embracing the End of a Business Journey.
Sometimes the hardest business decisions… are the right ones.In this episode, Krista shares the story behind closing her Deka Lash franchise — a decision that, from the outside, might look like failure, but from the inside was about clar...
The Real Cost of a Bad Hire (And How to Avoid It)
One bad hire doesn’t just cost you money…it costs you momentum, culture, and trust.If you’ve ever felt like you’re constantly cleaning up, overcompensating, or questioning your instincts after bringing someone onto your team — this episo...
The Art of Networking: How to Build Lasting Business Relationships.
Networking has a reputation for being fake, awkward, and exhausting.But what if that’s not actually true…what if we’ve just been doing it wrong?In this episode, Krista kicks off a new mini business masterclass series by unpa...